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New MRI could spot hidden heart disease in women without invasive scans

NCT ID NCT00832702

Knowledge-focused Sponsor: Cedars-Sinai Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Aug 28, 2026 · Updated 2 times

Summary

This study looks at whether a special heart MRI can find problems in the small arteries of women who have chest pain but no major blockages. About 375 women will get both a standard angiogram and a cardiac MRI to compare results. The goal is to see if the MRI can detect hidden heart issues without needing invasive procedures.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to a simpler, noninvasive way to diagnose hidden heart problems in women, improving detection and care.
What could go wrong
This is an observational study, not a treatment trial. The MRI method may not prove accurate enough to replace current tests, and results may not apply to all women.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 433 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2008

Expected to finish

Aug 2051

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Women undergoing clinically-ordered coronary angiography for suspected ischemia will be recruited. See the inclusion and exclusion criteria for details.

Ages

18 to 85 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Symptomatic angina or anginal equivalent; 2. Aged 18 years or older; 3. No obstructive CAD at coronary angiography (performed within the previous 24 months). 4. Competent to give informed consent. Exclusion Criteria: 1. Obstructive CAD ≥ 50% luminal diameter stenosis in ≥ 1 epicardial coronary artery, 2. Acute coronary syndrome (defined by the ACC/AHA criteria, Braunwald 2000), 3. Primary valvular heart disease clearly indicating the need for valve repair or replacement; 4. Patients with concurrent cardiogenic shock or requiring inotropic or intra-aortic balloon support; 5. Prior or planned percutaneous coronary intervention or CABG, 6. Acute MI; 7. Prior non-cardiac illness with an estimated life expectancy \< 4 years; 8. Unable to give informed consent; 9. Chest pain with a non-ischemic etiology (e.g.,pericarditis, pneumonia, esophageal spasm); 10. Contraindications to CMRI (e.g., AICD, pacemaker, untreatable claustrophobia or known angio-edema). 11. Contraindications to adenosine or Regadenoson (Lexiscan) 12. Women with intermediate coronary stenoses (\> 20% but \< 50% luminal diameter stenosis assessed visually at the time of angiography) will undergo clinically indicated IVUS testing based on the judgment of the operator; those determined to have flow-obstructing stenosis will be excluded from the overall study. 13. Participation in a research study that conflicts with the current WISE study. 14. Women with coronary stenosis ≥ 50% in any epicardial coronary artery, assessed visually at the time of angiography, will not be included in the CRT subgroup.

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder coronary microvascular disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiovascular disease

Contacts and locations

Locations

  • Cedars-Sinai Barbra Streisand Women's Heart Center

    Los Angeles, California, 90048, United States

  • University of Florida

    Gainesville, Florida, 32610-0277, United States

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