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Could artery disease drain the body's repair cells?

NCT ID NCT06626646

Knowledge-focused Sponsor: Canadian Medical and Surgical Knowledge Translation Research Group Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 21, 2026 · Last updated Aug 21, 2026

Summary

This study is looking at whether peripheral artery disease (PAD) is linked to lower levels of regenerative cells in the blood. Researchers will compare blood samples from adults with PAD to those without the condition, measuring the number of certain progenitor cells and markers of inflammation. The goal is to better understand how PAD affects the body's ability to repair blood vessels and overall cardiovascular health.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If this study finds that peripheral artery disease is linked to fewer regenerative cells in the blood, it could point toward new ways to monitor or treat cardiovascular risk.
What could go wrong
This is a small, observational study, so it can only show associations, not cause and effect. The results may not apply to broader populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

40 people

The number who actually took part.

Started

Oct 2024

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants will be identified from primary care and cardiology outpatient clinics in the Greater Toronto Area using paper-based and electronic medical records.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Adults ≥18 and ≤80 years of age who meet either of the following criteria: 1. Clinically significant/symptomatic PAD (defined as symptomatic claudication with and an ankle brachial index of less than 0.85). 2. No history of PAD. 2. Willing and able to provide written informed consent and comply with study procedures. Exclusion Criteria: 1. Unable or unwilling to provide written informed consent or to provide a peripheral blood sample. 2. Any life-threatening disease expected to result in death within two years. 3. Any malignancy not considered cured (except basal cell carcinoma of the skin). An individual is considered cured if there has been no evidence of cancer recurrence for the five years prior to screening. 4. Uncontrolled hypertension. 5. New York Heart Association Class IV heart failure. 6. Active liver disease or liver dysfunction. 7. Active kidney disease or kidney dysfunction. 8. History of hemorrhagic stroke or other major bleeding disorder. 9. White blood cell count of ≥15x10\^9/L. 10. Active infectious disease requiring systemic antibiotic or anti-viral agents. 11. Known acquired immunodeficiency syndrome, such as Human Immunodeficiency Virus. 12. On oral steroid therapy (e.g. prednisone or other corticosteroids) or other immunosuppressive agents (e.g. methotrexate). 13. Treated autoimmune disorders

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder peripheral arterial disease peripheral vascular disease type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiovascular disease Peripheral artery disease Peripheral vascular diseases Type 2 diabetes

Contacts and locations

Locations

  • Diagnostic Assessment Centre

    Scarborough Village, Ontario, M1S4N6, Canada

  • North York Diagnostic and Cardiac Centre

    North York, Ontario, M6B1N6, Canada

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