Cedars-sinai Medical Center

This study compares two standard procedures—minimally invasive TAVR and open-heart surgery (SAVR)—for replacing a diseased aortic valve in people with a bicuspid aortic valve. About 1,200 participants aged 50 and older with severe aortic stenosis will be randomly assigned to one …

This study tests whether mirabegron, a drug typically used for overactive bladder, can reduce dangerous heart rhythms in people with heart disease. Twenty adults with an implanted defibrillator and frequent ventricular tachycardia will take the drug for two months. Researchers wi…

This study tests a new adjustable cooler for storing donor hearts during transport to the transplant hospital. The cooler aims to keep the heart at a steady temperature, reduce waste, and lower costs compared to the current standard device. About 80 adults receiving a heart trans…

This pilot study tests whether giving people a choice between two weight management strategies—avoiding tempting foods or learning to resist them—helps them stick with the program better than being assigned a strategy. Sixty adults with overweight or obesity will either choose th…

This study tests whether a special low-calorie, plant-based diet taken for 5 days each month can safely improve blood flow to the brain in middle-aged adults who carry the APOE4 gene, which raises Alzheimer's risk. Forty participants aged 45-65 will be randomly assigned to either…

This pilot study will test a digital device that attaches to a standard COPD inhaler. The device coaches patients on proper inhaler technique and shares usage data with their healthcare team. Researchers want to see if this approach is practical and helps reduce hospital visits a…

This study tests whether taking S-adenosylmethionine (SAMe), a natural supplement, can prevent liver injury caused by the chemotherapy drug oxaliplatin. About 30 adults with colorectal cancer that has spread to the liver will take SAMe pills daily for 3-6 months alongside their c…

This study tests whether a natural supplement called SAMe can help prevent liver cancer in people with advanced fatty liver disease (MASLD) and cirrhosis. About 94 adults will receive either SAMe or a placebo for 12 months. Researchers will measure changes in a blood test that pr…

This study tests two online pain education programs for adults with Crohn's disease or ulcerative colitis who have chronic pain. Participants will complete a 2-hour online session and report their pain and quality of life weekly for 8 weeks. The goal is to see if these programs a…

This study compares two types of virtual reality (VR) during common ear, nose, and throat (ENT) procedures. One group will watch calming scenery, while the other plays an interactive puzzle game. Researchers want to see which better reduces pain and anxiety. The study will includ…

This phase 2 trial tests whether mirabegron, a drug currently used for overactive bladder, can reduce symptoms of Postural Orthostatic Tachycardia Syndrome (POTS). Thirty-six adults with confirmed POTS will receive either mirabegron or a placebo. The main goal is to see if the dr…

This study tests a 2-hour online class called Empowered Relief for 100 adults with advanced knee or hip osteoarthritis who cannot have joint replacement surgery. The class teaches simple pain management skills based on cognitive behavioral therapy and mindfulness. Researchers wil…

This study will test a culturally tailored online peer-support program for Korean-speaking breast cancer survivors and patients. Over 12 weeks, mentors (survivors) and mentees (patients in treatment) will interact through a bilingual platform. Researchers will measure whether the…

This study tests whether using a virtual reality headset at home can help adults with chronic pancreatitis manage their pain. Twenty participants will use either a gut-directed VR therapy or a distraction-based VR for 8 weeks. The main goal is to see if people can stick with the …

This study tests whether spraying a numbing medicine (bupivacaine with epinephrine) over the diaphragm during laparoscopic gynecologic surgery can reduce shoulder pain afterward. About 100 women will be randomly assigned to receive the spray or a placebo. The main goal is to see …