Common supplement SAMe tested to block liver cancer in fatty liver patients

NCT ID NCT07495995

First seen Apr 23, 2026 · Last updated May 07, 2026 · Updated 3 times

Summary

This study tests whether a natural supplement called SAMe can help prevent liver cancer in people with advanced fatty liver disease (MASLD) and cirrhosis. About 94 adults will receive either SAMe or a placebo daily for 12 months. Researchers will measure changes in a blood test that predicts liver cancer risk, and check for side effects. This is an early-phase trial to see if SAMe is worth studying further for this purpose.

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