New drug combo targets genetic fatty liver in Mid-Stage trial

NCT ID NCT07527910

Recruiting now Disease control Sponsor: Regeneron Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 11, 2026 · Updated 2 times

Summary

This Phase 2a trial is testing a new drug called ALN-PNP, alone or with a weight-loss drug (tirzepatide), in 204 adults with a specific genetic form of fatty liver disease (MASLD). The goal is to see if lowering a certain liver protein can reduce liver fat. Participants must have a high liver fat level and a specific gene variant.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ALN-PNP (a drug that lowers a protein linked to liver fat) and tirzepatide (a weight and blood sugar control drug)
What this could lead to: If successful, this could point toward a new treatment option for people with a genetic form of fatty liver disease, potentially reducing liver fat and improving liver health.
What could go wrong: This is an early Phase 2 trial with only 204 participants, so results may not apply to everyone. The drug may cause side effects or fail to reduce liver fat significantly.

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Conditions

The condition(s) this trial relates to.

metabolic dysfunction-associated steatotic liver disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE (MASLD)

Contacts and locations

Locations

Advanced Medical Trials
RECRUITING

Georgetown, Texas, 78628, United States
American Research Corporation
RECRUITING

Austin, Texas, 78757, United States
American Research Corporation at The Texas Liver Institute
RECRUITING

San Antonio, Texas, 78215, United States
California Liver Research Institute
RECRUITING

Pasadena, California, 91105, United States
Southern California Research Center
RECRUITING

Coronado, California, 92118, United States
Tandem Clinical Research, Plaza II
RECRUITING

Metairie, Louisiana, 70006, United States

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