Less invasive heart valve replacement put to the test against Open-Heart surgery
NCT ID NCT07413965
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares two standard procedures—minimally invasive TAVR and open-heart surgery (SAVR)—for replacing a diseased aortic valve in people with a bicuspid aortic valve. About 1,200 participants aged 50 and older with severe aortic stenosis will be randomly assigned to one of the two procedures. The goal is to see which approach is safer and more effective in the long run.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Transcatheter Aortic Valve Replacement (TAVR) and Surgical Aortic Valve Replacement (SAVR)
What this could lead to
If successful, this could show that a less invasive TAVR procedure is as safe and effective as open-heart surgery for people with bicuspid aortic valves, guiding better treatment choices.
What could go wrong
This is a large trial but has not started recruiting yet. Results may not apply to all patients, and TAVR may carry different risks (like stroke or need for reintervention) compared to surgery.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Cedars-Sinai Medical Center
Los Angeles, California, 90048, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••