Less invasive heart valve replacement put to the test against Open-Heart surgery
NCT ID NCT07413965
First seen Jun 25, 2026 · Last updated Aug 14, 2026 · Updated 2 times
Summary
This study compares two standard procedures—minimally invasive TAVR and open-heart surgery (SAVR)—for replacing a diseased aortic valve in people with a bicuspid aortic valve. About 1,200 participants aged 50 and older with severe aortic stenosis will be randomly assigned to one of the two procedures. The goal is to see which approach is safer and more effective in the long run.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Transcatheter Aortic Valve Replacement (TAVR) and Surgical Aortic Valve Replacement (SAVR)
- What this could lead to
- If successful, this could show that a less invasive TAVR procedure is as safe and effective as open-heart surgery for people with bicuspid aortic valves, guiding better treatment choices.
- What could go wrong
- This is a large trial but has not started recruiting yet. Results may not apply to all patients, and TAVR may carry different risks (like stroke or need for reintervention) compared to surgery.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Cedars-Sinai Medical Center
RECRUITINGLos Angeles, California, 90048, United States
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