Scientists hunt for genetic clues to aortic aneurysm risk

NCT ID NCT01194362

Completed Knowledge-focused Sponsor: Baylor Research Institute Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study collected blood and tissue samples from 91 adults with aortic valve disease to look for genetic differences that might explain why some develop aortic aneurysms. Researchers compared gene activity in people with bicuspid valves, tricuspid valves, and healthy controls. The goal is to better understand the disease, not to test a treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could help doctors understand why some people with aortic valve disease develop dangerous aneurysms, potentially leading to better screening or treatments.
What could go wrong: This is an observational study that only looks at genetic patterns, not a treatment. It may not lead to any direct medical changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Aortic Valve Disease aortic valve disease 1 aortic valve disorder aortic valve stenosis familial bicuspid aortic valve

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AORTIC VALVE DISEASE

Contacts and locations

Locations

The Heart Hospital Baylor Plano

Plano, Texas, 75093, United States

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