Baylor Research Institute

This study tests whether a small wireless monitor in the lung artery can help people with a mechanical heart pump avoid hospital visits. About 40 adults who already have a HeartMate III heart pump will be randomly assigned to get the monitor or standard care. The goal is to see i…

This study follows 225 adults who have the Ross procedure, a surgery that replaces a diseased aortic valve with the patient's own pulmonary valve. Researchers will track survival, hospital readmissions, and need for repeat surgeries over 1, 5, and 10 years. The goal is to confirm…

This study tests whether using a tiny ultrasound camera inside the blood vessels during a minimally invasive leg artery procedure leads to better results for people with peripheral artery disease. About 350 adults with leg pain or wounds from blocked arteries will be randomly ass…

This early-stage trial tests whether giving the drug bortezomib first can make metastatic triple-negative breast cancer more sensitive to two other drugs (pembrolizumab and cisplatin). About 20 women with advanced breast cancer that has already been treated with standard chemothe…

This study tests whether tirzepatide, a weight-loss medication, combined with standard hormone therapy can help clear tiny amounts of cancer DNA from the blood of people with obesity or overweight who have had hormone-positive, HER2-negative, node-positive early breast cancer. Th…

This study tracks 500 people who received a heart transplant from a donor with hepatitis C. Researchers want to see if using these organs is safe and works well. They will measure cure rates for hepatitis C, organ rejection, and survival after one year.

This study tests a weight-loss program delivered via telehealth for people who have had a stroke. The goal is to help participants lose weight and improve their health, especially those in underserved communities. The study will compare the program to a wait-list control group an…

This study tests whether hearts from donors with hepatitis C can be safely transplanted into people without the virus. Participants will receive antiviral medication after transplant to clear the infection. The goal is to expand the donor pool and reduce wait times for heart tran…

This phase 2 trial is testing whether adding the drug anakinra (Kineret) to standard chemotherapy can improve outcomes for people with pancreatic cancer that can be surgically removed or is locally advanced. Anakinra is an anti-inflammatory drug typically used for rheumatoid arth…

This early-phase trial tests whether combining two oral drugs, neratinib and ruxolitinib, is safe and can shrink tumors in people with metastatic triple-negative breast cancer that has come back on the chest wall after chemotherapy. About 20 women will take the drugs daily, and d…

This study is testing a culturally modified version of the Group Lifestyle Balance program for Hispanic/Latino people who have had a stroke. The program focuses on healthy eating and physical activity to help participants lose weight and reduce their risk of type 2 diabetes. Rese…

This study looks at whether giving a nitrate drug during a heart test can better detect blood flow problems in people who have chest pain but no blocked arteries. About 50 adults will get the standard test, then a repeat test after nitrates. The goal is to see if nitrates improve…

This study tests whether a short form of exposure therapy, given soon after a traumatic injury, can prevent posttraumatic stress disorder (PTSD). Researchers will enroll 300 injured adults admitted to Level I trauma centers. Half will receive the brief therapy plus standard care,…

This study tests if using a camera inside the heart (intracardiac echocardiography) is as safe and effective as the standard throat camera (transesophageal echocardiography) for guiding a procedure to close a heart pouch. The goal is to prevent strokes in people with an irregular…

This study tests whether using a robotic exoskeleton for walking practice helps stroke survivors recover their ability to walk better than standard physical therapy. The trial will enroll 54 adults who are in the early weeks after a stroke and are staying at a rehabilitation hosp…

This study tests whether a robotic exoskeleton can help people who had heart or lung surgery walk sooner and more safely in the ICU. Twenty adults will be randomly assigned to either use the exoskeleton or receive standard physical therapy. Researchers will measure how quickly pa…

This study tests a special shockwave balloon (intravascular lithotripsy) to safely widen heavily calcified arteries in the pelvis, allowing a less invasive heart valve replacement (TAVR) in patients who otherwise would need a more risky approach. About 50 adults with severe aorti…

This study tests a cream made from human milk fat to treat low blood sugar in newborns. About 75 babies at risk for low blood sugar will receive the cream instead of standard dextrose gel. The goal is to see if the cream can raise and keep blood sugar stable, reducing the need fo…

This study is building a large collection of blood, tissue, urine, and stool samples from 10,000 cancer patients across Texas. Researchers will match these samples with detailed medical records to study why some patients respond to cancer treatments while others do not. The goal …

This study looks at how bacteria in the gut (the microbiome) influence healing of leaks in the esophagus or stomach. Researchers will collect tissue and fluid samples from 50 adults during routine procedures to analyze microbial changes and the body's response. The goal is to und…

This study is creating a large registry of 14,000 people with peripheral artery disease (PAD) to compare the long-term results of treatments that use stents versus those that do not. Researchers will track outcomes like repeat procedures, amputations, and walking ability over 12 …

This study is building a bio-bank of blood samples from people who have had a lung transplant. Researchers will use these samples to study advanced lung diseases and improve transplant care. The goal is to better understand how infections and other factors affect patient outcomes…

This study explores how the bacteria in your gut and what you eat can influence chemotherapy-related diarrhea in colon cancer patients. Researchers will analyze stool samples and diet surveys from about 11 people receiving FOLFOX treatment. The goal is to create a tool that predi…

This study looks at whether doing a hard exercise test before a blood draw can make the AlloSure test better at spotting heart transplant rejection. Researchers will test 27 heart transplant recipients, both with stable transplants and those showing signs of rejection. The goal i…

This study looks at blood markers and how well transplanted insulin-making cells (islets) work in people with chronic pancreatitis who have their pancreas removed and get their own islets back. Researchers will follow 100 adults for at least two years to understand graft function…