Baylor Research Institute

This early-phase trial tests whether the drug bortezomib can make metastatic triple-negative breast cancer more sensitive to the immunotherapy pembrolizumab and chemotherapy cisplatin. About 20 women with advanced disease who have already received standard chemotherapy will recei…

This study compares two ways to guide a procedure that closes off a part of the heart to prevent strokes in people with atrial fibrillation. The standard method uses a probe down the throat (TEE), while the new method uses a probe inside the heart (ICE). The goal is to see if the…

This study tests if a special shockwave device, which uses sound waves to break up artery plaque, works as well as surgery for people with severely blocked leg arteries. About 60 adults with painful leg symptoms will be randomly assigned to get either the shockwave treatment or s…

This early-phase trial tests whether combining two drugs, neratinib and ruxolitinib, is safe and effective for people with metastatic triple-negative breast cancer that has come back on the chest wall after chemotherapy. About 20 women aged 18 and older will receive the drug comb…

This study tests a telehealth weight-loss program designed for people who have had a stroke. The goal is to help participants lose weight and improve their health, especially those who have limited access to in-person programs. About 94 adults who are at least one year past their…

This study tests whether tirzepatide, a weight-loss medication, can help eliminate tiny amounts of cancer left after standard treatment in people with obesity or overweight and a certain type of early breast cancer. About 48 participants will receive tirzepatide plus standard hor…

This study tests whether adding the anti-inflammatory drug anakinra to standard chemotherapy can help people with pancreatic cancer that can be removed by surgery. About 24 adults with early-stage or locally advanced pancreatic cancer will receive the drug combination before and …

This study tests whether using a tiny ultrasound camera inside the blood vessels during a minimally invasive leg artery procedure leads to better results for people with peripheral artery disease. About 350 adults with leg pain or wounds due to blocked arteries will be enrolled. …

This study looks at whether it is safe to use hearts from donors who have hepatitis C for heart transplants. Researchers will track 500 people who receive these hearts to see how well they do, including survival, rejection, and cure rates for hepatitis C. The goal is to expand th…

This study follows 225 adults with aortic valve disease who undergo the Ross procedure, a surgery that replaces the diseased valve with the patient's own pulmonary valve. Researchers will track survival, hospital readmissions, and need for repeat surgeries over 1, 5, and 10 years…

This study tests whether hearts from donors with hepatitis C can be safely transplanted into people without the virus. Recipients will take antiviral medication to prevent infection. The goal is to expand the donor pool and improve survival for people with heart failure.

This study tests a healthy lifestyle program that has been adapted for Hispanic/Latino people who have had a stroke. The goal is to help participants lose weight and improve health markers like blood sugar and cholesterol. The program includes a smart scale for home use and in-pe…

This study tests a new way to treat people with severe aortic stenosis who also have heavily calcified leg arteries that normally block a less invasive heart valve replacement. Doctors use a special balloon that sends sound waves to crack the calcium, making room for the valve de…

This study tests whether a brief form of exposure therapy, given soon after a serious injury, can prevent posttraumatic stress disorder (PTSD). Researchers will enroll 300 adults admitted to Level I trauma centers. Participants will be randomly assigned to receive the brief thera…

This study tests a cream made from pasteurized donor breast milk as a treatment for low blood sugar in newborns. The cream is given to at-risk babies (e.g., born to mothers with diabetes or born early) who are otherwise healthy. Researchers want to see if the cream stabilizes blo…

This study tests whether a robotic exoskeleton can help people walk sooner and more safely after heart or lung surgery. About 20 adults will either use the robotic suit or receive standard physical therapy. The goal is to see if the robot helps patients get moving earlier without…

This study compares robotic gait training to standard physical therapy for people recovering from a stroke. Researchers want to see if using a robotic exoskeleton early in rehab improves walking speed and ability. The study involves 54 adults aged 18-85 who are in inpatient rehab…

This study aims to collect and store blood, tissue, urine, and stool samples from up to 10,000 cancer patients across Texas. Researchers will use these samples to study how the immune system responds to cancer treatments and find markers that predict which therapies work best. Th…

This study is collecting information from 14,000 people with peripheral artery disease (PAD) to compare outcomes between those who received a stent and those who received other treatments without a stent. Researchers will track events like repeat procedures, amputations, and walk…

This study collects blood and tissue samples from 100 adults who have had a lung transplant in the last 10 years. Researchers will use these samples to study biomarkers and how infections affect outcomes. The goal is to improve care for people with advanced lung disease, not to t…

This study looks at how a common heart medication, nitroglycerin, changes blood flow measurements in the small blood vessels of the heart. Researchers will test 50 adults who have chest pain but no major blockages in their arteries. The goal is to better understand how these vess…

This study looks at how well insulin-producing cells (islets) work after being transplanted back into people with chronic pancreatitis who had their pancreas removed. Researchers will collect blood samples to measure inflammation and graft function. The goal is to understand what…

This study looks at the bacteria and other microbes involved when people develop a leak in their esophagus or stomach after surgery or injury. Researchers want to understand how these microbes change over time and how the body responds, so they can find better ways to help the le…

This study looks at how the bacteria in your gut and what you eat can influence diarrhea caused by chemotherapy in people with colon cancer. Researchers will collect stool samples and diet surveys from 11 participants to build a tool that predicts who is at higher risk for this s…

This study looks at whether exercising before a blood test called AlloSure can make it better at spotting early signs of heart transplant rejection. Researchers will test 27 heart transplant recipients, both with stable and active immune responses. The goal is to see if a simple …