Baylor Research Institute

This study tests a wireless device that stimulates the vagus nerve during rehabilitation exercises to help people who have had a stroke recover arm and hand function. The approach, called targeted plasticity therapy, aims to enhance the brain's ability to rewire itself. The trial…

This study compares a new, less invasive shockwave device to standard surgery for treating severe calcium buildup in the main leg artery. The shockwave uses sound waves to break up the calcium, while surgery involves physically removing the blockage. Researchers want to see if th…

This study tests two procedures—G-POEM and a gastric electrical stimulator—for people with severe gastroparesis (stomach paralysis) that hasn't improved with medication. Forty adults will be randomly assigned to one of two groups to compare safety and symptom relief. The goal is …

This study is testing whether a uterus transplant from a living or deceased donor can help women who were born without a uterus or had it removed to have a baby. Up to 38 women with working ovaries will receive a transplant and then try to get pregnant through IVF. The main goal …

This study aimed to see if taking antibiotics for three days after a type of prostate surgery (HoLEP) lowers the chance of getting a urinary tract infection. It was designed for men over 40 with an enlarged prostate and no current infection. However, the study was withdrawn befor…

This study tests a combination of two drugs, abemaciclib and ramucirumab, in people with advanced esophageal or gastroesophageal junction cancer that has spread. The goal is to see if this treatment is safe and can help control tumor growth. About 8 participants are enrolled, and…

This early-phase trial aimed to test whether curcumin (the active compound in turmeric) could safely help treat cervical precancer (CIN3). It planned to give 500 mg of curcumin twice daily for 12 weeks to women with CIN3. However, the study was withdrawn before enrolling any part…

This study tests if giving the blood thinner heparin as a shot under the skin is as safe and effective as the standard method of giving it through an IV for adults on ECMO (a machine that helps the lungs). The goal is to see if the shot method causes fewer bleeding or clotting pr…

This study tests whether the drug everolimus can lower the risk of liver cancer coming back after a liver transplant in patients with high-risk hepatocellular carcinoma. About 336 adults who have just received a transplant will be randomly assigned to take everolimus plus tacroli…

This study aimed to see if using cold saline to inflate a balloon inside the uterus could reduce blood loss after childbirth better than room temperature saline. It was designed for women aged 18-45 who had just given birth vaginally and had uncontrolled bleeding. However, the st…

This study aimed to test whether giving antibody-rich plasma from recovered COVID-19 patients could help hospitalized adults with pneumonia caused by the virus. The trial was withdrawn before any participants were enrolled, so no data was collected. The approach was based on the …

This study tests a weight-loss program designed for people with traumatic brain injury (TBI). About 57 adults with moderate to severe TBI and a BMI of 25 or higher will join. The program focuses on healthy eating and physical activity, tracking weight, step count, and blood press…

This study tests a healthy lifestyle program designed for people who have had a stroke. The program focuses on weight loss and increasing physical activity. Researchers will track 65 participants for 12 months to see if the program helps them achieve and maintain a healthier weig…

This study tests a weight-loss program delivered via telehealth, specifically designed for people with traumatic brain injury (TBI). The program is adapted from the Diabetes Prevention Program and addresses unique needs of TBI patients. Researchers aim to see if the program helps…

This study tests whether a workshop led by fellow firefighters can help prevent PTSD, depression, anxiety, and alcohol problems in new firefighter recruits. About 480 trainees will take part in either an emotion regulation workshop or a standard education session during their aca…

This study tests four different numbing medicines (lidocaine, bupivacaine, chlorprocaine, and mepivacaine) to see which one causes the least pain when re-injected during Mohs skin cancer surgery. About 400 adults having Mohs surgery will rate their pain on a 1-10 scale. The goal …

This study compares a new non-opioid drug, suzetrigine, to the standard opioid painkiller hydrocodone/acetaminophen for pain after Mohs skin cancer surgery. Researchers want to see if suzetrigine can control pain just as well while reducing the need for opioids. The trial involve…

This study aimed to compare three tube feeding methods—bolus, gravity, and pump—in 60 head and neck cancer patients undergoing chemoradiation. The goal was to see which method leads to the least weight loss and best tolerance. However, the trial was withdrawn before any patients …

This phase 2 trial compares two numbing medications—BDE (a mix of bupivacaine, dexamethasone, and epinephrine) and Exparel—to see which one reduces pain better after hernia surgery. About 128 adults having abdominal wall reconstruction will receive one of the drugs during a nerve…

This study tests a device that stimulates the vagus nerve during arm rehabilitation exercises to see if it helps people with spinal cord injuries regain upper limb function. Twenty adults with chronic cervical spinal cord injury will receive either active or placebo stimulation d…

This study was designed to compare a tiny steroid insert (Dextenza) placed in the tear duct against standard steroid eye drops (prednisolone) after cataract surgery in people with diabetes. The goal was to see which better controls eye inflammation and swelling. However, the stud…

This study tests whether wearing a special helmet that shines near-infrared light on the head can help brain cells work better and protect themselves. About 100 people with early to mid-stage dementia will wear the helmet regularly for 8 weeks. Researchers will check memory, thin…

This study planned to test a laparoscopic-guided nerve block (TAP block) to reduce opioid painkiller use after weight-loss or anti-reflux stomach surgeries. It compared two numbing medicines, Bupivacaine HCL and Exparel. However, the trial was withdrawn before enrolling any parti…

This study tests whether corticosteroids can improve swallowing in people with a rare esophagus disorder called EGJOO, where food gets stuck. Researchers suspect an allergy may cause the problem. Twelve adults with swallowing difficulties or chest pain will receive the medication…

This study tests whether an Enhanced Recovery After Surgery (ERAS) protocol can reduce the need for strong painkillers after a kidney transplant from a living donor. Sixty adult participants will receive a carbohydrate drink, Tylenol, gabapentin, a local numbing injection, and ea…

This study tests whether a short form of talk therapy, called brief prolonged exposure therapy, can help prevent post-traumatic stress disorder (PTSD) in people who have had a spinal cord injury. The therapy involves three one-hour sessions during inpatient rehabilitation. Resear…

This study looks at whether cardiac MRI is safe and helpful for people who have abandoned, fractured, or permanently implanted heart wires (leads). Researchers will monitor patients during and after the scan to check for any problems and see how well the images work for diagnosis…

This study aims to improve mental health care for minority groups by training students from diverse backgrounds to become certified community health workers. About 1500 undergraduate students will receive training and internships to help their communities address mental health is…

This study tracks 300 adults in the Bonton neighborhood to see how taking part in farm-based wellness activities (like healthy eating and exercise programs) affects their heart health and quality of life over one year. Participants choose which activities to join, and researchers…

This study looks at how common anesthetics change the way the esophagus moves during a special imaging procedure called FLIP. Researchers will measure muscle flexibility and contraction in 30 adults with swallowing problems like achalasia. The goal is to better understand how ane…

This study aims to learn why some people do not join cancer prevention research. Researchers will interview 15 adults aged 30 to 70 to identify barriers and improve outreach. The goal is to make future studies more representative of all communities in the United States.

This study looks at how athletes aged 10-22 who have had a concussion respond to sport-specific exercise. The goal is to find better ways to decide when it's safe for them to return to play. Researchers will measure things like heart rate, blood pressure, and symptoms during exer…