Baylor Research Institute

This study is testing a culturally adapted healthy lifestyle program designed specifically for Hispanic/Latino stroke survivors. The 12-month program helps participants lose weight through diet and exercise guidance that respects their cultural background. Researchers want to see…

This study is testing whether using ultrasound imaging inside blood vessels during leg artery procedures helps patients with poor leg circulation. Researchers want to see if this imaging technique leads to better blood flow, fewer repeat procedures, and improved quality of life. …

This study is testing if adding a drug called anakinra, which reduces inflammation, to standard chemotherapy can better control pancreatic cancer in patients who are candidates for surgery. The goal is to see if this combination helps shrink tumors before surgery, improves surviv…

This early-phase trial is testing a new treatment strategy for metastatic triple-negative breast cancer that has stopped responding to standard chemotherapy. Researchers want to see if giving the drug bortezomib first can make the cancer more vulnerable to a later combination of …

This study is testing if a newer, less invasive procedure using a special Shockwave balloon is as safe and effective as traditional surgery for treating severe, hardened blockages in the main leg artery. Researchers will randomly assign 60 participants with painful leg cramps or …

This study is testing whether a weight loss program delivered through telehealth (video calls and online support) can help people who have had a stroke. Researchers will compare the program to a waitlist group to see if it helps participants lose weight and improve health markers…

This study follows patients who undergo the Ross procedure, a special type of heart valve surgery. The procedure replaces a damaged aortic valve with the patient's own living pulmonary valve, avoiding the need for lifelong blood thinners required with mechanical valves. Researche…

This study is testing a new wireless device designed to help people regain movement after a stroke. The device gently stimulates a nerve in the neck during physical therapy exercises, aiming to help the brain re-learn how to control the arm and hand. Researchers want to see if th…

This study is testing if adding the weight loss medication tirzepatide to standard hormone therapy can help prevent breast cancer from spreading in overweight patients. It focuses on people with early-stage, hormone-positive breast cancer who have a high risk of recurrence, as sh…

This study looks at whether using hearts from donors who tested positive for hepatitis C is safe for transplant patients. Researchers will track 500 people who received these transplants to see how well they do. The goal is to understand the risks and benefits, which could help m…

This study is testing a technique called intravascular lithotripsy (IVL), which uses tiny shockwaves, to break up severe calcium deposits in the leg arteries of patients who need a heart valve replacement. The goal is to see if clearing this blockage safely allows doctors to perf…

This study tests whether hearts from donors with hepatitis C can be safely transplanted into patients without hepatitis C. After transplant, patients receive antiviral medication to treat the hepatitis C infection they receive from the donor heart. The goal is to expand the pool …

This early-stage trial is testing the safety and effectiveness of combining two drugs, neratinib and ruxolitinib, for a difficult-to-treat form of breast cancer. It is for people whose triple-negative breast cancer has spread and returned to the chest wall after previous chemothe…

This study is testing a special cream made from pasteurized human donor milk as a new way to treat low blood sugar in newborns. Researchers want to see if this cream, given instead of a standard sugar gel, can better raise and stabilize a baby's blood sugar levels, potentially ke…

This study is testing if having heart transplant patients exercise before a special blood test makes the test better at detecting early signs of organ rejection. Researchers want to see if the stress of exercise causes more donor DNA to appear in the blood when there is a problem…

This study is testing whether a brief, three-session therapy can prevent posttraumatic stress disorder (PTSD) in people who have been seriously injured. Researchers will enroll 300 patients admitted to Level 1 trauma centers and randomly assign them to receive either the brief th…

This study compares robotic gait training to standard physical therapy for people recovering from stroke during inpatient rehabilitation. Researchers will test whether using a robotic exoskeleton helps patients walk faster, farther, and more safely than traditional methods. The t…

This study is testing whether a robotic exoskeleton suit can help patients walk sooner and more safely after major heart or chest surgery. Researchers will compare patients using the robot-assisted walking program to those receiving standard physical therapy. The main goals are t…

This large observational study is collecting real-world data to compare how well two common treatments—using stents versus not using stents—work for people with peripheral artery disease (PAD) in their legs. It will follow 14,000 patients who have already had one of these procedu…

This study is creating a large collection of blood, tissue, and other samples from up to 10,000 cancer patients in Texas. The goal is to help scientists learn why some patients respond well to treatments like immunotherapy while others do not. By analyzing these samples alongside…

This study aims to understand how well transplanted insulin-producing cells work in people with chronic pancreatitis who have their pancreas removed. Researchers will collect blood samples from 100 participants to track markers of inflammation and cell function. The goal is to ga…

This study aims to understand how the community of bacteria in your gut (the microbiome) and what you eat might influence the risk and severity of diarrhea caused by chemotherapy for colon cancer. Researchers will collect stool samples, diet records, and blood from about 11 parti…

This study aims to understand how the community of bacteria in the gut changes when a leak occurs after stomach or esophagus surgery. Researchers will collect fluid and tissue samples from 50 adult patients who have developed such leaks. By comparing these samples, they hope to l…

This study collects blood and tissue samples from people with advanced lung diseases or who have had lung transplants. Researchers will store these samples in a biobank to study them later, looking for biological markers that could help diagnose conditions earlier or predict how …