Could a common blood pressure drug help dementia with lewy bodies?

NCT ID NCT04760860

Not yet recruiting Symptom relief Sponsor: Qiang Zhang Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage trial will test whether terazosin, a drug currently used for high blood pressure and enlarged prostate, is safe and tolerable for people with dementia with Lewy bodies. Forty participants will receive either terazosin or a placebo for 15 weeks. The study focuses on side effects and how well people stick with the treatment, not on whether it improves symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Terazosin hydrochloride (a drug usually used for high blood pressure or enlarged prostate)
What this could lead to: If it works, this could point toward a new way to ease motor symptoms in dementia with Lewy bodies.
What could go wrong: This is a very early, small trial (40 people) focused on safety and tolerability, not on proving the drug works. It may fail to show benefit or cause side effects like low blood pressure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Lewy body dementia Lewy Body Disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEMENTIA WITH LEWY BODIES

Contacts and locations

Locations

University of Iowa

Iowa City, Iowa, 52252, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.