Heart surgery without opioids: a safer path to recovery?
NCT ID NCT07618130
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares opioid-free anesthesia to standard opioid-based anesthesia in 400 adults having elective heart surgery. The goal is to see if avoiding opioids can reduce both short-term and long-term pain, while also lowering side effects like delirium and nausea. Patients will be randomly assigned to one of two groups, and pain levels will be tracked for 48 hours after surgery and again at 3 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Opioid-free anesthesia (a mix of non-opioid drugs and nerve blocks)
What this could lead to
If it works, this could offer a safer way to manage pain after heart surgery, reducing the risk of addiction and side effects like nausea or confusion.
What could go wrong
This is an early-stage trial with no phase assigned, so results are uncertain. The opioid-free approach may not control pain as well as standard methods, and individual responses can vary.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Clinical Center of Serbia
Belgrade, Serbia