Could a neck surgery slow Alzheimer's? new trial aims to find out

NCT ID NCT07658430

Not yet recruiting Disease control Sponsor: Southwest Hospital, China Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a surgical procedure called deep cervical lymphovenous anastomosis (LVA) for people with moderate Alzheimer's disease. The surgery aims to improve the brain's ability to clear waste proteins, like amyloid-beta, which are linked to Alzheimer's. Researchers will compare 148 people who get the surgery plus standard medication against 148 who get only medication, tracking their cognitive function and brain changes over 12 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: deep cervical lymphovenous anastomosis (LVA) surgery
What this could lead to: If successful, this could offer a new surgical option to slow cognitive decline in moderate Alzheimer's by improving the brain's waste-clearing system.
What could go wrong: This is an early-stage surgical trial with no prior efficacy data in Alzheimer's. The procedure carries surgical risks, and the benefit over standard drug treatment is unproven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER'S DISEASE

Contacts and locations

Locations

The First Affiliated Hospital of Army Medical University (Southwest Hospital)

Chongqing, Chongqing Municipality, 400038, China

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