Heart hole closure may rewire migraine brains, study hints
NCT ID NCT07343154
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at 45 adults with migraine and a small hole in the heart (PFO). Researchers will use brain scans and thinking tests to see if closing the hole changes brain activity, mood, and migraine symptoms over a year. The goal is to understand the link between PFO and migraine, not to prove a new treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
percutaneous patent foramen ovale (PFO) closure procedure
What this could lead to
If successful, this study could clarify whether closing a PFO improves brain function and reduces migraine burden, pointing toward a better understanding of migraine mechanisms.
What could go wrong
This is a small, early-phase observational study (45 participants) that does not test a new drug or therapy. It may not show clear benefits, and results may not apply to all migraine patients.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.