New drug masitinib could slow Alzheimer's decline

NCT ID NCT05564169

Not yet recruiting Disease control Sponsor: AB Science Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 trial tests whether masitinib, a drug that targets immune cells in the brain, can slow cognitive decline in 600 people with mild Alzheimer's. Participants take masitinib or a placebo alongside standard Alzheimer's medications. The study lasts 24 weeks and measures changes in thinking and daily function.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: masitinib
What this could lead to: If it works, this could point toward a new treatment option to slow cognitive decline in people with mild Alzheimer's disease.
What could go wrong: This is an early Phase 3 trial, and previous studies of similar drugs have failed. Masitinib may not show benefit, and side effects from the drug are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER DISEASE

Contacts and locations

Locations

Ace Alzheimer Center Barcelona (Fundació ACE)

Barcelona, Spain
Complejo Asistencial de Zamora. Hospital Provincial de Zamora

Zamora, Spain
Hospital Clinico Universitario Virgen de la Arrixaca

Murcia, Spain
Hospital Policlínico de Gipuzkoa

Donostia / San Sebastian, Spain
Hospital Universitario Nuestra Señora del Perpetuo Socorro de Albacete (Hospital Universitario Nuestra Señora del Perpétuo Socorro)

Albacete, Spain
Hospital Universitario de Navarra

Pamplona, Spain
Institut de la mémoire et Maladie d'Alzheimer, Hôpitaux Universitaires Pitié-Salpêtrière

Paris, France
La Paz University Hospital (Hospital Universitario La Paz)

Madrid, Spain
Virgen de las Nieves University Hospital (Hospital Universitario Virgen de las Nieves)

Granada, Spain

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