Neck surgery aims to flush Alzheimer's proteins from the brain

NCT ID NCT07458620

Not yet recruiting Disease control Sponsor: Chang Gung Memorial Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-stage trial tests whether a minimally invasive neck surgery, called lymphaticovenular anastomosis (LVA), is safe for people with Alzheimer's disease. The surgery connects tiny lymph vessels in the neck to nearby veins, creating a detour to help the brain drain harmful waste proteins. Thirty-five participants will be followed for 12 months to check for side effects and measure changes in memory and brain scans.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Supermicrosurgical Lymphaticovenular Anastomosis (LVA) surgery
What this could lead to: If safe, this could point toward a new surgical approach to help the brain clear harmful proteins, potentially slowing Alzheimer's progression.
What could go wrong: This is a very early Phase 1 safety trial with only 35 people. The surgery is invasive and may not improve symptoms; risks include surgical complications and anesthesia side effects.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease dementia neurodegenerative disease Plaque, Amyloid

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER'S DISEASE(AD)

Contacts and locations

Locations

Kaohsiung Chang Gung Memorial Hospital

Kaohsiung City, 833, Taiwan

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Other studies related to the condition(s) this trial covers.