Blood test could revolutionize Alzheimer's diagnosis, reducing need for spinal taps and scans

NCT ID NCT07680335

Recruiting now Diagnosis Sponsor: Alzheimercentrum Amsterdam Source: ClinicalTrials.gov ↗

First seen Jul 02, 2026 · Last updated Jul 02, 2026

Summary

This study looks at whether measuring certain proteins in the blood (p-tau217 and neurofilament light) can help doctors diagnose Alzheimer's disease more quickly and confidently in people with memory problems. About 550 participants visiting a memory clinic will have their blood tested, and researchers will track how the results change the diagnosis and the doctor's certainty. The goal is to see if blood-based biomarkers can replace or reduce the need for more invasive or expensive tests like spinal taps or brain scans.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Plasma p-tau217 and neurofilament light chain blood test
What this could lead to: If successful, this could make Alzheimer's diagnosis faster, less invasive, and more accessible, helping patients get the right care sooner.
What could go wrong: The study is observational and does not test a treatment. Blood tests may not be accurate enough in all cases, and results may not change how doctors manage patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER BLOOD BIOMARKERS ALZHEIMER'S DISEASE(AD)

Contacts and locations

Locations

Amsterdam UMC
RECRUITING

Amsterdam, North Holland, 1081HV, Netherlands
Dijklander Ziekenhuis
RECRUITING

Purmerend, Netherlands
Elisabeth-TweeSteden Ziekenhuis
NOT_YET_RECRUITING

Tilburg, Netherlands
Flevoziekenhuis
RECRUITING

Almere Stad, Netherlands
Frisius MC
RECRUITING

Leeuwarden, Netherlands
Jeroen Bosch Ziekenhuis
RECRUITING

's-Hertogenbosch, Netherlands
Spaarne Gasthuis
RECRUITING

Haarlem, Netherlands
Tergooi MC
RECRUITING

Hilversum, Netherlands

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