Neck surgery may help clear Alzheimer's toxins from the brain

NCT ID NCT07669272

Not yet recruiting Disease control Sponsor: Southwest Hospital, China Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a one-time microsurgery that connects lymphatic vessels in the neck to veins, aiming to improve drainage of waste proteins from the brain. Fifty-nine people with severe Alzheimer's will receive the surgery plus standard medication. Researchers will measure changes in cognitive function and brain scans over 12 months to see if the procedure is safe and effective.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Deep Cervical Lymphovenous Anastomosis (a microsurgical procedure to connect lymphatic vessels to neck veins)
What this could lead to: If successful, this could offer a new way to slow cognitive decline in severe Alzheimer's by helping the brain clear toxic proteins.
What could go wrong: This is a very early, small study with no control group, so results may not be reliable. Surgery carries risks like infection or anesthesia complications, and the benefit is unproven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease Cognitive Dysfunction dementia neurodegenerative disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER'S DISEASE

Contacts and locations

Locations

The First Affiliated Hospital of Army Medical University (Southwest Hospital)

Chongqing, Chongqing Municipality, 400038, China

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