Major trial takes on Alzheimer's tau tangles with multiple drugs

NCT ID NCT06957418

First seen Nov 01, 2025 · Last updated May 14, 2026 · Updated 29 times

Summary

This study tests whether drugs that target tau protein, alone or with another drug (donanemab), can slow Alzheimer's in people aged 50–80 with very early symptoms. About 900 participants will receive different treatments or placebos over 30 months, with regular brain scans and memory tests. The goal is to find a safe way to reduce tau buildup and delay disease progression.

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Contacts and locations

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