Could a common diabetes drug boost brain power in schizophrenia?
NCT ID NCT05838573
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether metformin, a drug used for diabetes, can improve cognitive problems in people with schizophrenia. 120 participants took either metformin or a placebo for 24 weeks. Researchers measured changes in thinking skills and brain scans to see if metformin helps.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
metformin
What this could lead to
If it works, this could point toward a new way to help with thinking and memory problems in people with schizophrenia.
What could go wrong
This is a completed phase 3 trial, but results are not yet reported. Metformin is generally safe, but it may not improve cognition, and the effect may be small.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Mental Health Institute of Second Xiangya Hospital,CSU
Changsha, Hunan, 410011, China
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Shandong Mental Health Center
Jinan, Shandong, 250014, China
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The Second People's Hospital of Dali Bai Autonomous Prefecture
Dali, Yunnan, 671014, China
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The Third Peoples's Hospital of Jiangyin
Jiangyin, Jiangsu, 214400, China