Zapping the brain while training memory: a new hope for MCI?

NCT ID NCT04246164

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study tested whether combining a gentle brain stimulation technique called HD-tDCS with computer-based cognitive training is feasible for people with mild cognitive impairment (MCI). Eight participants completed 15 sessions over three months. The main goal was to see if people would stick with the treatment, not to prove it works. Early results suggest the approach is worth studying further in larger trials.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
high definition transcranial direct current stimulation (HD-tDCS) combined with cognitive training
What this could lead to
If this approach proves feasible and effective in larger trials, it could point toward a non-drug way to slow memory decline in people with mild cognitive impairment.
What could go wrong
This is a very small pilot study with only 8 participants, so results may not apply to everyone. The main goal was feasibility, not proof of benefit, and larger studies are needed.

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Conditions

The condition(s) this trial relates to.

cognitive disorder Cognitive Dysfunction Memory Disorders

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • The Medical College of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.