Could this pill boost brain function in lewy body dementia?

NCT ID NCT05869669

Completed Symptom relief Sponsor: EIP Pharma Inc Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested an experimental drug called neflamapimod in 159 people with dementia with Lewy bodies (DLB). The goal was to see if it could improve memory, problem-solving, and attention compared to a placebo. Participants took the drug or a dummy pill for a set period, and researchers measured changes in thinking and daily function.

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Conditions

The condition(s) this trial relates to.

Lewy body dementia Lewy Body Disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEMENTIA WITH LEWY BODIES

Contacts and locations

Locations

AdventHealth Neuroscience Research

Orlando, Florida, 32804, United States
Banner Alzheimer's Institute - Edson Family Lewy Body Dementia Center

Tucson, Arizona, 85718, United States
Banner Sun Health Research Institute

Sun City, Arizona, 85351, United States
Barrow Neurological Institute

Phoenix, Arizona, 85013, United States
Belfast Health & Social Care Trust

Belfast, BT12 6BA, United Kingdom
Brain Research Center - Amsterdam

Amsterdam, 1081, Netherlands
Brain Research Center - Den Bosch

's-Hertogenbosch, 5223, Netherlands
Brain Research Center - Zwolle

Zwolle, 8025, Netherlands
Cambridgeshire and Peterborough NHS Foundation Trust, Fulbourn Hospital - Windsor Research Unit

Cambridge, CB215EF, United Kingdom
Campus Ageing Research Unit (CARU) - Newcastle upon Tyne, CNTW NHS Foundation Trust

Newcastle upon Tyne, NE4 5PL, United Kingdom
Center for Cognitive Health

Portland, Oregon, 97225, United States
Cleveland Clinic - Center for Brain Health

Cleveland, Ohio, 44195, United States
Cleveland Clinic - Lou Ruvo Center for Brain Health

Las Vegas, Nevada, 89106, United States
ClinCloud

Melbourne, Florida, 32940, United States
Columbia University - Taub Institute/Neurology Dept

New York, New York, 10032, United States
Cornwall Partnership NHS Foundation Trust (University of Exeter)

Redruth, TR15 3QE, United Kingdom
Georgetown Univ Hospital - Dept of Neurology

Washington D.C., District of Columbia, 20007, United States
Hoag Memorial Hospital Presbyterian

Newport Beach, California, 92663, United States
Houston Methodist Hospital - Stanley Appel Neurology Dept

Houston, Texas, 77030, United States
JEM Research Institute

Lake Worth, Florida, 33462, United States
Johns Hopkins School of Medicine - Dept of Neurology

Baltimore, Maryland, 21287, United States
Mass General Hospital/Harvard Medical School - Dept of Neurology

Charlestown, Massachusetts, 02129, United States
Mayo Clinic - Alzheimer's Disease Research Center

Rochester, Minnesota, 55905, United States
Memory Assessment and Research Centre (MARC) - Moorgreen Hospital

Southampton, SO30 3JB, United Kingdom
NeuroScience Research Center

Canton, Ohio, 44718, United States
Ohio State University - Dept of Neurology

Columbus, Ohio, 43221, United States
Panhandle Research and Medical Clinic

Pensacola, Florida, 32503, United States
Re:Cognition Health

London, W1G9JF, United Kingdom
SC3 Research Group

Pasadena, California, 91105, United States
Sana Research

Arlington, Virginia, 22205, United States
South London and Maudsley NHS Foundation Trust

London, SE5 8AF, United Kingdom
Stanford Neuroscience Health Center

Palo Alto, California, 94304, United States
Tandem Clinical Research

Marrero, Louisiana, 70072, United States
UCSD Health Sciences - Movement Disorders Center

La Jolla, California, 92037, United States
University College London (UCL) Clinical Research Facility, University College London Hospitals NHS Foundation Trust

London, WC1N 3BG, United Kingdom
University of Colorado - Dept of Neurology

Aurora, Colorado, 80045, United States
University of Kansas Medical Center

Kansas City, Kansas, 66160, United States
University of Nebraska Medical Center - Dept of Neurological Sciences

Omaha, Nebraska, 68198, United States
University of North Carolina - Dept of Neurology

Chapel Hill, North Carolina, 27599, United States
Virginia Commonwealth University - Parkinson's and Movement Disorders Center

Richmond, Virginia, 23298, United States

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