Brain 'Firmness' test may spot Alzheimer's early
NCT ID NCT06029114
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
Researchers at Mayo Clinic are testing whether measuring brain stiffness with a special MRI scan (magnetic resonance elastography) can serve as a new biomarker for Alzheimer's disease. The study will enroll 450 adults, including healthy volunteers, people with mild cognitive impairment, and those with Alzheimer's. Participants undergo a brain scan that measures tissue stiffness, which may change with disease progression.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Magnetic Resonance Elastography (MRE) scan
What this could lead to
If successful, this could lead to a new, non-invasive way to detect Alzheimer's disease earlier using a simple MRI-based scan.
What could go wrong
This is an observational study, not a treatment trial. Brain stiffness may not prove to be a reliable or practical biomarker for routine diagnosis.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Mayo Clinic Minnesota
Rochester, Minnesota, 55905, United States