Pedal power: could cycling delay Alzheimer's in High-Risk seniors?

NCT ID NCT04748861

First seen Nov 01, 2025 · Last updated May 23, 2026 · Updated 36 times

Summary

This study looks at whether regular, high-intensity indoor cycling can slow down or delay Alzheimer's disease in healthy older adults who carry a specific genetic risk (APOE ε4). About 150 inactive people aged 65-80 will use a Peloton bike at home for a long-term exercise program. Researchers will track changes in memory, brain volume, and fitness to see if exercise helps protect the brain.

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Contacts and locations

Locations

  • Cleveland Clinic

    Cleveland, Ohio, 44195, United States

Conditions

Explore the condition pages connected to this study.