New study tests if exercise can save your muscles while on Weight-Loss drugs

NCT ID NCT07554417

Not yet recruiting Disease control Sponsor: William Marsh Rice University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a 12-week program of exercise and personalized diet counseling can help preserve muscle mass in obese adults taking GLP-1 medications like Wegovy. Twenty participants aged 40-55 will be followed to see if these lifestyle changes prevent the muscle loss often seen with rapid weight loss. The goal is to make GLP-1 treatment safer and more effective.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Semaglutide (Wegovy), plus dietary counseling and exercise
What this could lead to: If it works, this could show that adding exercise and diet counseling to GLP-1 treatment helps preserve muscle mass while losing weight, leading to safer weight management.
What could go wrong: This is a very small early-phase trial with only 20 participants, so results may not apply to everyone. The exercise program is supervised and may be hard to maintain long-term.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for DIETARY ASSESSMENT are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

muscular atrophy Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIETARY ASSESSMENT EXERCISE INTERVENTION GLP-1 MUSCLE LOSS OBESITY & OVERWEIGHT

Contacts and locations

Locations

Rice University

Houston, Texas, 77005, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.