Can keeping blood pressure higher during surgery prevent organ damage?

NCT ID NCT04789733

Ongoing Knowledge-focused Sponsor: The Cleveland Clinic Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study tests whether keeping blood pressure higher than usual during and after major surgery can reduce serious complications like heart attack, kidney injury, and confusion. About 80 adults aged 45 and older who take blood pressure medication and are having long surgeries will be randomly assigned to either tight or routine blood pressure management. The goal is to see if this approach is feasible and safe before a larger trial.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: norepinephrine or phenylephrine (medicines to raise blood pressure)
What this could lead to: If it works, this could point toward a standard way to manage blood pressure during surgery to lower the risk of serious complications.
What could go wrong: This is a very small pilot study with only 80 people, so results may not apply widely. The tight control approach could also cause side effects like too-high blood pressure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute kidney injury cardiovascular disorder delirium

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GENERAL SURGERY

Contacts and locations

Locations

China Japan Union Hospital of Jilin University

Changchun, Jilin, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.