PET scans probe link between brain inflammation and Alzheimer's damage

NCT ID NCT05911178

Ongoing Knowledge-focused Sponsor: Centre Hospitalier St Anne Source: ClinicalTrials.gov ↗

First seen Jul 22, 2026 · Last updated Jul 23, 2026 · Updated 1 time

Summary

This study uses advanced PET scans to investigate how brain inflammation and tau protein buildup affect synaptic density in people with Alzheimer's disease. Researchers will compare Alzheimer's patients to healthy controls over two years, tracking changes in these brain markers. The goal is to better understand the disease's progression and refine patient subgroups for future treatment trials.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PET tracers ([11C]-UCB-J, [18F]-DPA-714, [18F]-RO-948, [11C]-PiB) used for brain imaging
What this could lead to: Could help identify distinct Alzheimer's subtypes based on brain inflammation and tau patterns, leading to more targeted treatments.
What could go wrong: This is an observational imaging study, not a treatment trial. It may not directly lead to new therapies, and results may not apply to all Alzheimer's patients.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease Neuroinflammatory Diseases

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER DISEASE

Contacts and locations

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Locations

CHU de Lille

Lille, France
CHU de Rouen

Rouen, France
GHU Saint Anne Psychiatrie & Neurosciences

Paris, France

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