Hope for rare brain disease: new drug aims to delay death or paralysis
NCT ID NCT05819866
First seen Nov 17, 2025 · Last updated Apr 24, 2026 · Updated 14 times
Summary
This study tests a drug called leriglitazone in adult men with cerebral adrenoleukodystrophy (cALD), a rare and serious brain disease. The goal is to see if the drug can delay death or the need for permanent breathing support compared to a placebo. About 40 men who cannot or choose not to have a stem cell transplant will take part.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Federal University of Sao Paulo
RECRUITINGSão Paulo, Brazil
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Health University of Utah
WITHDRAWNSalt Lake City, Utah, 84112, United States
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Hospital 12 de Octubre
RECRUITINGMadrid, 28041, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Austral
RECRUITINGBuenos Aires, Argentina
Contact Phone: •••-•••-•••• Email: •••••@•••••
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ICM La Pitie Salpetriere
RECRUITINGParis, 75013, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Kennedy Krieger Institute
RECRUITINGBaltimore, Maryland, 21205, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Klinik und Poliklinik für Neurologie-Leipzig
RECRUITINGLeipzig, 04103, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Massachusetts General Hospital
RECRUITINGBoston, Massachusetts, 02114, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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National Hospital for Neurology and Neurosurgery
RECRUITINGLondon, WC1N 3AX, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Neuro Medicine Hospital / UF Health
WITHDRAWNGainesville, Florida, 32608, United States
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Sir Ganga Ram Hospital
RECRUITINGNew Delhi, 110060, India
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Stanford University Medical Center
RECRUITINGPalo Alto, California, 94304-5978, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Minnesota
RECRUITINGMinneota, Minnesota, 55455, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Conditions
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