Could a natural hormone rebuild brains in Alzheimer's?
NCT ID NCT04838301
First seen Jun 24, 2026 · Last updated Jul 01, 2026 · Updated 3 times
Summary
This phase 2 trial tests whether allopregnanolone, a natural hormone, can safely help repair the brain in people with early Alzheimer's disease. About 100 volunteers aged 55 to 80 will receive weekly infusions of the drug or a placebo for several months. Researchers will measure changes in brain volume and memory performance.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
allopregnanolone
What this could lead to
If it works, this could point toward a treatment that slows or reverses brain shrinkage in Alzheimer's disease.
What could go wrong
This is an early phase 2 trial with only 100 people, so results may not be conclusive. The drug may not improve memory or thinking, and side effects are still being studied.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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ATP Clinical Research
Costa Mesa, California, 92626, United States
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Combined Research Orlando
Orlando, Florida, 32807, United States
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Conquest Research
Winter Park, Florida, 32789, United States
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MedVadis Research
Waltham, Massachusetts, 02451, United States
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Miami Jewish Health
Miami, Florida, 33137, United States
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Optimus U Corporation
Miami, Florida, 33135, United States
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Perseverance Research Center
Scottsdale, Arizona, 85253, United States
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Syrentis Clinical Research
Santa Ana, California, 92705, United States
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University of Arizona / Clinical & Translational Sciences Research Center
Tucson, Arizona, 85721, United States