Could a natural hormone rebuild brains in Alzheimer's?

NCT ID NCT04838301

Ongoing Disease control Sponsor: University of Arizona Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 01, 2026 · Updated 3 times

Summary

This phase 2 trial tests whether allopregnanolone, a natural hormone, can safely help repair the brain in people with early Alzheimer's disease. About 100 volunteers aged 55 to 80 will receive weekly infusions of the drug or a placebo for several months. Researchers will measure changes in brain volume and memory performance.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: allopregnanolone
What this could lead to: If it works, this could point toward a treatment that slows or reverses brain shrinkage in Alzheimer's disease.
What could go wrong: This is an early phase 2 trial with only 100 people, so results may not be conclusive. The drug may not improve memory or thinking, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease Alzheimer disease 2 neurodegenerative disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER DEMENTIA LATE ONSET ALZHEIMER DISEASE NEURODEGENERATIVE DISEASES

Contacts and locations

Locations

ATP Clinical Research

Costa Mesa, California, 92626, United States
Combined Research Orlando

Orlando, Florida, 32807, United States
Conquest Research

Winter Park, Florida, 32789, United States
MedVadis Research

Waltham, Massachusetts, 02451, United States
Miami Jewish Health

Miami, Florida, 33137, United States
Optimus U Corporation

Miami, Florida, 33135, United States
Perseverance Research Center

Scottsdale, Arizona, 85253, United States
Syrentis Clinical Research

Santa Ana, California, 92705, United States
University of Arizona / Clinical & Translational Sciences Research Center

Tucson, Arizona, 85721, United States

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