Could a spinal injection slow Alzheimer's? new trial underway

NCT ID NCT05399888

Ongoing Disease control Sponsor: Biogen Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 01, 2026 · Updated 2 times

Summary

This Phase 2 study tests an experimental drug called BIIB080 in people with mild cognitive impairment or mild dementia due to Alzheimer's disease. The drug is injected into the fluid around the spinal cord every 12 or 24 weeks. Researchers want to see if it can slow the worsening of symptoms compared to a placebo. The study involves 416 participants and lasts about 4 years, including a long-term extension where everyone can receive the drug.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

BIIB080 (a drug injected into the fluid around the spinal cord)

What this could lead to

If it works, this could point toward a treatment that slows the worsening of Alzheimer's symptoms, helping people stay independent longer.

What could go wrong

This is an early Phase 2 trial, so results may not confirm benefit. The drug is injected into the spine, which carries risks like headache or infection. It may not slow the disease at all.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER'S DISEASE DEMENTIA MILD COGNITIVE IMPAIRMENT DUE TO ALZHEIMER'S DISEASE

Contacts and locations

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Locations

AMC Research, LLC

Matthews, North Carolina, 28105, United States
AZ Groeninge

Kortrijk, 8500, Belgium
Advent Health

Orlando, Florida, 32804, United States
Azienda Ospedaliera Card. G. Panico

Tricase, Lecce, 73039, Italy
Azienda Ospedaliera Universitaria Policlinico Umberto I - Università di Roma La Sapienza

Roma, 185, Italy
Azienda Ospedaliera e Universitaria di Perugia

Perugia, 06156, Italy
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili)

Brescia, 25123, Italy
Banner Sun Health Research Institute

Sun City, Arizona, 85351, United States
Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02216, United States
Boston Center for Memory

Newton, Massachusetts, 02459, United States
Brain Research Center Amsterdam

Amsterdam, Amsterdam, Netherlands
Brigham and Women's Hospital Department of Neurology

Boston, Massachusetts, 02115-5804, United States
Butler Hospital

Providence, Rhode Island, 02906, United States
CAE Oroitu

Getxo, Vizcaya, 48993, Spain
CHU Nantes - Hopital Nord Laënnec

Saint-Herblain, Loire Atlantique, 44800, France
CHU Strasbourg - Hôpital Hautepierre

Strasbourg, Bas Rhin, 67000, France
CHU de Rouen - Hôpital Charles Nicolle

Rouen, Seine Maritime, 76031, France
CRST, Clinical Research Services Turku

Turku, 20520, Finland
Care Clinic Centrum Medyczne

Katowice, 40568, Poland
Center for Neurosciences

Tucson, Arizona, 85718, United States
Centrum Medyczne Senior

Sopot, 81-855, Poland
Charing Cross Hospital

London, Greater London, W6 8RF, United Kingdom
Charité - Campus Charité Mitte

Berlin, 10117, Germany
Charité - Universitätsmedizin Berlin

Berlin, 13125, Germany
Charter Research, LLC

Lady Lake, Florida, 32159, United States
Charter Research, LLC

Winter Park, Florida, 32792, United States
Clinica Universidad de Navarra

Pamplona, Navarre, 31008, Spain
Clinique de la Memoire de l'Outaouais

Gatineau, Quebec, J8T 8J1, Canada
Cliniques Universitaires Saint-Luc

Brussels, 1200, Belgium
Conquest Research

Winter Park, Florida, 32789, United States
Dent Neurologic Institute

Amherst, New York, 14226, United States
Deutsches Zentrum fuer Neurodegenerative Erkrankungen (DZNE)

Bonn, North Rhine-Westphalia, 53127, Germany
Duke University

Durham, North Carolina, 27710, United States
Ehime University Hospital

Toon-shi, Ehime, 791-0295, Japan
EvergreenHealth

Kirkland, Washington, 98034, United States
FORBELI s.r.o.

Prague, 16000, Czechia
Fakultni nemocnice Hradec Kralove

Hradec Králové, 50005, Czechia
Fakultni nemocnice Ostrava

Ostrava, 70852, Czechia
Fakultni nemocnice u sv. Anny v Brne

Brno, 65691, Czechia
Fakultni nemocnice v Motole

Prague, 150 06, Czechia
Fondazione IRCCS Istituto Neurologico Carlo Besta

Milan, 20133, Italy
Fondazione Istituto G.Giglio di Cefalù

Cefalù, Palermo, 90015, Italy
Fundacio ACE

Barcelona, 8028, Spain
Greater Manchester Mental Health NHS Foundation Trust

Manchester, Greater Manchester, M13 9WL, United Kingdom
Groupe Hospitalier Pitie-Salpetriere

Paris, 75013, France
Hawaii Pacific Neuroscience

Honolulu, Hawaii, 96817, United States
Himeji Central Hospital Clinic

Himeji-shi, Hyōgo, 672-8043, Japan
HonorHealth Neurology

Scottsdale, Arizona, 85251, United States
Hopital Gui de Chauliac

Montpellier, Herault, 34295, France
Hopital Purpan

Toulouse, Haute Garonne, 31059, France
Hopital Roger Salengro - CHU Lille

Lille, Nord, 59037, France
Hospital Clinic de Barcelona

Barcelona, 8036, Spain
Hospital Universitari de Santa Maria

Lleida, 25198, Spain
Hospital Universitari i Politecnic La Fe

Valencia, 46026, Spain
Hospital Universitario Dr. Peset

Valencia, 46017, Spain
Hospital Universitario Reina Sofia

Córdoba, 14004, Spain
Hospital Victoria Eugenia

Seville, 41009, Spain
Hospital de la Santa Creu i Sant Pau

Barcelona, 8025, Spain
Hôpital La Grave

Toulouse, Haute Garonne, 31059, France
Hôpital Lariboisière

Paris, Paris, 75010, France
Hôpitaux Universitaires de Genève - HUG- Centre de la mémoire, Bâtiment A1 - Morier

Geneva, 1205, Switzerland
Institute of Psychiatry, Psychology and Neuroscience

London, Greater London, SE5 8AF, United Kingdom
Itä-Suomen yliopisto, Kuopion kampus

Kuopio, 70210, Finland
Jewish General Hospital - NETWORK

Montreal, Quebec, H3T 1E2, Canada
K2 Medical Research, LLC

Orlando, Florida, 32751, United States
Kantonsspital St. Gallen

Sankt Gallen, 9007, Switzerland
Karolinska universitetssjukhuset - Huddinge

Stockholm, 14186, Sweden
Katholisches Klinikum Bochum gGmbH

Bochum, 44791, Germany
Kingfisher Cooperative, LLC

Spokane, Washington, 99202, United States
Klinikum Altenburger Land GmbH

Altenburg, Thuringia, 4600, Germany
Klinikum Bayreuth GmbH- Hohe Warte

Bayreuth, Bavaria, 95445, Germany
Klinikum der Universität München

München, Bavaria, 81377, Germany
Lahey Clinic Medical Center - Burlington

Burlington, Massachusetts, 01805, United States
Liverpool Hospital

Liverpool, New South Wales, 2170, Australia
Mary S. Easton Center for Alzheimer's Disease Research, UCLA

Los Angeles, California, 90095, United States
Mater Hospital Brisbane

South Brisbane, Queensland, 4101, Australia
Mazowiecki Szpital Wojewódzki w Warszawie Sp z oo

Warsaw, 03-242, Poland
Medical Arts Health Research Group

West Vancouver, British Columbia, V7T 1C5, Canada
Montreal Neurological Institute Clinical Research Unit

Montreal, Quebec, H3A 2B4, Canada
Neuro Centrum Science GmbH

Erbach im Odenwald, Hesse, 64711, Germany
NeuroClin Limited

Motherwell, Strathclyde, ML1 4UF, United Kingdom
NeuroProtect Sp. z o.o.

Warsaw, 01-684, Poland
NeuroScience Research Center, LLC.

Canton, Ohio, 44718, United States
Neurological Associates of Albany, PC

Albany, New York, 12208, United States
Neurology Clinic, PC

Cordova, Tennessee, 38018, United States
Neurology Consultants of Dallas, PA

Dallas, Texas, 75243, United States
New York University Medical Center PRIME

New York, New York, 10016, United States
Nippon Medical School Musashi Kosugi Hospital

Kawasaki-shi, Kanagawa, 211-8533, Japan
Nzoz Novo-Med

Katowice, 40-650, Poland
Osaka Metropolitan University Hospital

Osaka, Osaka, 545-8586, Japan
Osaka University Hospital

Suita-shi, Osaka, 565-0871, Japan
Ospedale Regionale di Lugano

Lugano, Canton Ticino, 6903, Switzerland
Ospedale San Raffaele

Milan, 20132, Italy
Ospedale di Arzignano

Arzignano VI, Vicenza, 36071, Italy
PNS Clinical Research, LLC dba

Orange, California, 92868, United States
PROMENTE Sp. z o.o.

Bydgoszcz, 85-133, Poland
Podlaskie Centrum Psychogeriatrii

Bialystok, 15-756, Poland
Re Cognition Health Bristol

Bristol, BS32 4SY, United Kingdom
Re:Cognition Health - Birmingham

Birmingham, West Midlands, B16 8LT, United Kingdom
Re:Cognition Health Ltd (London)

London, Greater London, W1G 9RU, United Kingdom
Recherches Neuro-Hippocampe Inc., d/b/a Ottawa Memory Clinic

Ottawa, Ontario, K1Z 1G3, Canada
Rigshospitalet

Copenhagen, 2100, Denmark
Rocky Mountain Movement Disorders Center, PC

Englewood, Colorado, 80113, United States
Royal Hallamshire Hospital

Sheffield, South Yorkshire, S10 2JF, United Kingdom
Royal Prince Alfred Hospital

Camperdown, New South Wales, 2050, Australia
SPZOZ Centralny Szpital Kliniczny UM w Lodzi

Lodz, 92-213, Poland
SPZOZ Szpital Uniwersytecki w Krakowie

Krakow, 30-688, Poland
SUNY Upstate Medical University

Syracuse, New York, 13210, United States
Sahlgrenska Universitetssjukhuset, Mölndal Sjukhus

Mölndal, 43180, Sweden
Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie Kliniczny Oddział Neurologii Oddział Udarowy

Lublin, 20-954, Poland
South Shore Neurologic Associates, P.C.

Patchogue, New York, 11772, United States
Southampton General Hospital

Southampton, Hampshire, SO16 6YD, United Kingdom
Southern Neurology

Kogarah, New South Wales, 2217, Australia
Spitalzentrum Biel

Biel/Bienne, 2501, Switzerland
St Vincent's Hospital Sydney

Darlinghurst, New South Wales, 2010, Australia
Stanford Hospital and Clinics

Palo Alto, California, 94304, United States
Sutter Institute for Medical Research

Sacramento, California, 95816, United States
The Medical Arts Health Research Group

Kamloops, British Columbia, V2C 5T1, Canada
The National Hospital for Neurology and Neurosurgery Centre

London, Greater London, WC1N 3BG, United Kingdom
Tokyo Metropolitan Institute for Geriatrics and Gerontology

Itabashi-ku, Tokyo-To, 173-0015, Japan
Toronto Memory Program (Neurology Research Inc.)

Toronto, Ontario, M3B 2S7, Canada
UBC Hospital

Vancouver, British Columbia, V6T 2B5, Canada
UZ Brussel

Brussels, 1090, Belgium
UZ Leuven

Leuven, 3000, Belgium
Universitaetsklinikum Koeln

Cologne, North Rhine-Westphalia, 50937, Germany
Universitaetsklinikum Tuebingen

Tübingen, Baden-Wurttemberg, 72076, Germany
Universitaetsklinikum Ulm

Ulm, Baden-Wurttemberg, 89081, Germany
Universitaetsmedizin Goettingen

Göttingen, Lower Saxony, 37075, Germany
Universitaetsmedizin Mannheim

Mannheim, Baden-Wurttemberg, 68167, Germany
University of California San Diego Medical Center

San Diego, California, 92103, United States
University of California San Francisco (PARENT)

San Francisco, California, 94143, United States
University of Cincinnati Physicians Group, LLC

Cincinnati, Ohio, 45206-0829, United States
University of Texas Health Science Center at San Antonio

San Antonio, Texas, 78229, United States
Vestra Clinics s.r.o.

Rychnov nad Kněžnou, 516 01, Czechia
Warneford Hospital

Oxford, Oxfordshire, OX3 7JX, United Kingdom
Xenoscience Inc.

Phoenix, Arizona, 85004, United States
Yokohama City Minato Red Cross Hospital

Yokohama, Kanagawa, 231-8682, Japan
Ålborg Universitets Hospital

Aalborg, 9100, Denmark