Could atomoxetine or metformin be the next Alzheimer's treatment?
NCT ID NCT07724132
First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time
Summary
This Phase 3 trial is testing whether two existing drugs—atomoxetine, typically used for ADHD, and metformin, a diabetes medication—can slow cognitive and functional decline in people with Alzheimer's disease. Around 1,200 participants aged 55 and older with mild to moderate Alzheimer's will receive one of the drugs or a placebo for 18 months. Researchers will measure changes in memory, thinking skills, and daily living abilities to see if either drug offers a benefit.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- atomoxetine and metformin, two existing drugs repurposed for Alzheimer's disease
- What this could lead to
- If successful, this could point toward new, readily available treatments to slow cognitive decline in Alzheimer's disease.
- What could go wrong
- These are repurposed drugs not originally designed for Alzheimer's, and the trial is still testing whether they work at all. Side effects from atomoxetine or metformin may limit tolerability.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Two Bridges Research & Development Clinic
RECRUITINGChertsey, KT16 9AU, United Kingdom
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Windsor Research Unit
RECRUITINGCambridge, CB21 5EF, United Kingdom
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