Can speech therapy slow language loss in progressive aphasia?
NCT ID NCT04881617
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests two types of speech therapy for people with primary progressive aphasia, a brain disorder that slowly destroys language skills. Sixty participants will work on word retrieval or script practice with a clinician and at home. Researchers will measure changes in communication and use brain scans to see who benefits most.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Lexical Retrieval Training and Video-Implemented Script Training for Aphasia (behavioral therapy)
- What this could lead to
- If it works, this could provide evidence-based speech therapy methods to help people with primary progressive aphasia communicate better for longer.
- What could go wrong
- This is a small, early-stage study with only 60 participants, and the disease is progressive, so any improvements may be temporary or not work for everyone.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of California San Francisco
San Francisco, California, 94158, United States
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University of Texas
Austin, Texas, 78712, United States
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