Logopenic progressive aphasia

This study tests whether combining home-based brain stimulation (tDCS) with virtual speech therapy can improve communication in adults with primary progressive aphasia, a language disorder often caused by Alzheimer's disease. Eighty participants will receive either active or plac…

This study tests whether custom 3D-printed cutlery handles can help people with neurodegenerative diseases eat more independently. 75 patients in rehabilitation care will try handles in different sizes, designed to fit their grip. Researchers will measure changes in eating abilit…

This Phase II trial tests whether a safe, non-invasive brain stimulation technique called tDCS, combined with language therapy, can improve word-finding in people with primary progressive aphasia (PPA). The study enrolls 180 adults aged 50–90 with certain types of PPA. Participan…

This study tests a personalized, virtual speech therapy program for people with primary progressive aphasia (a type of dementia that affects language) and their communication partners. The goal is to see if the program improves communication and quality of life. About 30 particip…

This study tests whether a gentle electrical current applied to specific brain areas can boost the effects of language therapy in people with logopenic variant primary progressive aphasia (lvPPA), a form of Alzheimer's that mainly affects language. Sixty participants will receive…

This study tests whether a non-invasive technique called repetitive Transcranial Magnetic Stimulation (rTMS) can improve memory and brain function in older adults with mild cognitive impairment or early Alzheimer's. Over 30 participants will receive both real and sham (placebo) s…

This study looks at people with brain damage from strokes, tumors, or other conditions to understand why they have specific thinking problems. Researchers will use brain scans and cognitive tests to link brain areas to deficits. The goal is to learn more about how the brain works…

This study gathers medical information from 200 adults with possible nerve, muscle, or autonomic nervous system disorders who are not already in other NIH studies. Participants undergo standard tests like nerve conduction studies, EMG, and physical exams. The data is stored anony…

This study is looking at how people with conditions like schizophrenia, bipolar disorder, depression, and neurological diseases (such as Alzheimer's or stroke) perform on computer-based thinking tests. The goal is to create a detailed map of cognitive strengths and weaknesses acr…

This study looks at whether using a swallow gel or a semi-solid vehicle can help people with neurological conditions swallow pills more easily and safely. Researchers will observe 500 participants, including patients with swallowing disorders and healthy volunteers, as they swall…