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Can we predict psychosis? global study seeks answers

NCT ID NCT05905003

Ongoing Knowledge-focused Sponsor: Brigham and Women's Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This observational study is collecting data from 2,617 young people (ages 12-30) at clinical high risk for psychosis, plus healthy controls, across 13 countries. Researchers will use clinical assessments, cognitive tests, and biomarkers to build algorithms that predict who will recover, who will develop psychosis, and who will have ongoing symptoms. The goal is to improve early detection and pave the way for future treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this could lead to better prediction tools to identify which young people at high risk for psychosis will recover, worsen, or develop schizophrenia, enabling earlier and more targeted interventions.
What could go wrong
This is an observational study, not a treatment trial, so it won't directly test any therapy. The algorithms developed may not be accurate enough for widespread clinical use without further validation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

conversion disorder psychotic disorder Psychotic Disorders

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CLINICAL HIGH RISK CONVERSION PSYCHOSIS REMISSION

Contacts and locations

Locations

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts, 02115, United States

  • Copenhagen Research Center for Mental Health (CORE)

    Copenhagen, DK-2900, Denmark

  • Department of Psychiatry, Chonnam National University Hospital & Mindlink

    Gwangju, 61469, South Korea

  • Early Psychosis Intervention Programme (EPIP) Clinic, Institute of Mental Health

    Singapore, 539747, Singapore

  • Forward Thinking Birmingham

    Birmingham, B4 6DF, United Kingdom

  • HEP and co-located Headspace Adelaide

    Adelaide, South Australia, 5000, Australia

  • Hartford Healthcare

    Hartford, Connecticut, 06106, United States

  • Headspace Melton

    Melton South, Victoria, 3338, Australia

  • Headspace, Craigieburn

    Craigieburn, Victoria, 3064, Australia

  • Headspace, Glenroy

    Glenroy, Victoria, 3046, Australia

  • Headspace, Sunshine

    Sunshine, Victoria, 3020, Australia

  • Headspace, Werribee

    Werribee, Victoria, 3030, Australia

  • Hospital Clínico Universidad de Chile (HCUCH)

    Santiago, Santiago Metropolitan, 8380456, Chile

  • Icahn School of Medicine at Mount Sinai

    New York, New York, 10029, United States

  • Instituto de Psiquiatría y Salud Mental Hospital General Universitario Gregorio Marañón

    Madrid, Spain

  • King's College London

    London, SE5 8AF, United Kingdom

  • Klinik für Psychiatrie und Psychotherapie, University of Cologne

    Cologne, Brescia, 50931, Germany

  • Ludwig-Maximilians-Universität Munich

    Munich, Germany

  • McGill University

    Montreal, Quebec, H4H 1R3, Canada

  • Northwell Health

    Queens, New York, 11004, United States

  • Northwestern University

    Evanston, Illinois, 60201, United States

  • Orygen Specialist Programs, Melbourne

    Parkville, Victoria, 3122, Australia

  • Seoul National University College of Medicine

    Seoul, 03082, South Korea

  • Shanghai Jiao Tong University

    Shanghai, 200030, China

  • Temple University

    Philadelphia, Pennsylvania, 19122, United States

  • The University Hospital Jena, Department of Psychiatry

    Jena, Thuringia, 07743, Germany

  • The University of Hong Kong, Department of Psychiatry

    Hong Kong, Hong Kong

  • Treatment and Early Intervention in Psychosis Program (TIPP) & Center for Psychiatric Neuroscience (CNP), Department of Psychiatry, Lausanne University Hospital

    Lausanne, 1008, Switzerland

  • University of Calgary

    Calgary, Alberta, Canada

  • University of California Irvine

    Irvine, California, 92697, United States

  • University of California Los Angeles

    Los Angeles, California, 90095,, United States

  • University of California San Diego

    San Diego, California, 92103, United States

  • University of California San Francisco

    San Francisco, California, 94121, United States

  • University of Cambridge

    Cambridge, CB4 1PR, United Kingdom

  • University of Georgia

    Athens, Georgia, 30602, United States

  • University of North Carolina at Chapel Hill

    Chapel Hill, North Carolina, 27599, United States

  • University of Oregon

    Eugene, Oregon, 97401, United States

  • University of Pavia

    Pavia, Pavia, 27100, Italy

  • University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • University of Pittsburgh

    Pittsburgh, Pennsylvania, 15213, United States

  • Washington University

    St Louis, Missouri, 63110, United States

  • Yale University/Connecticut Mental Health Center

    New Haven, Connecticut, 06519, United States

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