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Scientists hunt for clues in genes and body fluids to unlock ALS mysteries

NCT ID NCT04875416

Ongoing Knowledge-focused Sponsor: University of Miami Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is observing 217 people with ALS and related conditions like frontotemporal dementia and hereditary spastic paraplegia. Researchers aim to connect each person's genetic makeup with their symptoms and find biological markers in blood and spinal fluid. No new treatments are being tested; the goal is to gather knowledge that could improve future clinical trials.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this could help design better future clinical trials by identifying reliable ways to measure disease progression in specific genetic groups.
What could go wrong
This is an observational study, not a treatment trial. It will not directly improve symptoms or slow disease. Results may take years to influence care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

amyotrophic lateral sclerosis frontotemporal dementia hereditary spastic paraplegia lateral sclerosis motor neuron disorder progressive muscular atrophy spinal muscular atrophy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AMYOTROPHIC LATERAL SCLEROSIS FRONTOTEMPORAL DEMENTIA HEREDITARY SPASTIC PARAPLEGIA PRIMARY LATERAL SCLEROSIS PROGRESSIVE MUSCULAR ATROPHY

Contacts and locations

Locations

  • University of Cape Town

    Cape Town, South Africa

  • University of Kansas Medical Center

    Kansas City, Kansas, 66160, United States

  • University of Miami

    Miami, Florida, 33136, United States

  • University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

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