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Can a brain implant let paralyzed people control computers with their minds?

NCT ID NCT05035823

Disease control Sponsor: Synchron Medical, Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 08, 2026 · Last updated Sep 09, 2026 · Updated 1 time

Summary

This study tests a device called a motor neuroprosthesis, an implantable brain computer interface designed to help people with severe paralysis control digital devices like computers or tablets. The device aims to bypass damaged motor pathways and transmit brain signals directly to a computer. Researchers are evaluating the safety and feasibility of the implant in a small group of participants with severe quadriparesis, which can result from conditions like stroke, spinal cord injury, or ALS. The study focuses on whether the device can be safely implanted and used to perform digital commands.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Motor NeuroProsthesis (MNP), an implantable brain computer interface
What this could lead to
If it works, this could give people with severe paralysis a way to control computers and other digital devices using their thoughts, restoring some independence.
What could go wrong
This is a very early feasibility study with only 6 participants, so it may not lead to a widely available treatment. The implant procedure carries risks such as infection, bleeding, or device-related complications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

6 people

The number who actually took part.

Started

Apr 2022

Expected to finish

Sep 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Severe quadriparesis 2. Able to give consent 3. Appropriate candidate for neurointerventional procedure 4. Able and willing to access all clinical testing and not impeded by geographical location 5. Proficient in English 6. Have a study partner Exclusion Criteria: 1. Active condition resulting in immunosuppression 2. Unsuitable for general anesthesia 3. Anaphylactic allergy to contrast media 4. Allergy to nickel 5. History of pulmonary embolism 6. History of recent deep vein thrombosis 7. Psychiatric or psychological disorder 8. No study partner or caregiver 9. Unable to provide evidence of COVID vaccination

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Conditions

The condition(s) this trial relates to.

amyotrophic lateral sclerosis brain stem infarction cerebral infarction muscular dystrophy nervous system disorder palsy quadriplegia spinal cord injury spinal muscular atrophy stroke disorder Stroke, Lacunar

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Amyotrophic lateral sclerosis Cervical spinal cord injury Muscular dystrophies Neurologic disorder Paralysis Paralysis; stroke Quadriplegia/tetraplegia Spinal cord injuries Spinal muscular atrophy Stroke brainstem Stroke, lacunar Tetraplegic; paralysis

Contacts and locations

Locations

  • Mount Sinai Health System

    New York, New York, 10029, United States

  • University at Buffalo Neurosurgery (UBNS)

    Buffalo, New York, 14203, United States

  • University of Pittsburgh Medical Center

    Pittsburgh, Pennsylvania, 15213, United States

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