Brain scans reveal secrets of cognitive decline after injury
NCT ID NCT05922748
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study uses brain imaging techniques like MRI and EEG to explore how brain lesions cause cognitive deficits such as reading or visual perception problems. Researchers will study 1,500 patients and healthy volunteers using a detailed single-case approach. The goal is to better understand the brain mechanisms behind these deficits, not to test a new treatment.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this study could improve our understanding of how brain injuries cause cognitive problems, potentially guiding future rehabilitation strategies.
- What could go wrong
- This is an observational, exploratory study, not a treatment trial. It is not designed to test a therapy, so direct patient benefits are unlikely in the near term.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 1,500 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Feb 2014
- Expected to finish
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Feb 2027
An estimate. End dates often move.
- Lead sponsor
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A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
INCLUSION CRITERIA Common criteria for patients and healthy volunteers: * Age: 18 years and older * Affiliation with a social security system * Signed informed consent * No psychotropic medication intake in the week prior to the examination, and no alcohol consumption on the eve of the examination (subjects will be instructed to have a good night's sleep before the examination). Specific criteria for patients: \- Patients must present either cerebral lesions (vascular, malformative, tumoral) or traumatic injuries, or a history of neonatal or congenital conditions that may result in selective cognitive impairments, or congenital or acquired visual perception disorders. NON INCLUSION CRITERIA Common criteria for patients and volunteers: * Pregnant, lactating, or postpartum women (except for purely behavioral tests). * Individuals with visual or auditory deficits that would interfere with the tasks to be performed during brain imaging acquisition. * Contraindications for MRI (except for purely behavioral tests): * Cardiac or neural stimulation devices * Ferromagnetic surgical clips * Cochlear implants * Intra-ocular metallic foreign bodies or objects in the nervous system * Implants or metallic objects that may concentrate the radiofrequency field * Lack of informed consent * Claustrophobia
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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ICM - Paris Brain Institute
Paris, Île-de-France Region, 75013, France
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