Major study aims to unlock mysteries of Early-Onset Alzheimer's

NCT ID NCT03507257

Ongoing Knowledge-focused Sponsor: Indiana University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 30, 2026 · Updated 2 times

Summary

This study follows 850 people aged 40-64 with early-onset cognitive impairment to understand how Alzheimer's disease progresses. Participants undergo cognitive tests, brain scans, and genetic analysis, but no experimental treatment is given. The goal is to gather data that could improve future diagnosis and care.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease Cognition Disorders Cognitive Dysfunction dementia early-onset autosomal dominant Alzheimer disease Pick disease Plaque, Amyloid

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER DISEASE EARLY-ONSET ALZHEIMER DISEASE MILD COGNITIVE IMPAIRMENT

Contacts and locations

Locations

Amsterdam UMC

Amsterdam, 1081 HZ, Netherlands
Banner Sun Health Research Institute

Sun City, Arizona, 85351, United States
Butler Hospital

Providence, Rhode Island, 02906, United States
Columbia University

New York, New York, 10032, United States
Emory University

Atlanta, Georgia, 30322, United States
Fleni

Buenos Aires, C1428 CABA, Argentina
Georgetown University

Washington D.C., District of Columbia, 20057, United States
Hospital de la Santa Creu i Sant Pau

Barcelona, 8041, Spain
Houston Methodist Hospital

Houston, Texas, 77030, United States
Indiana University

Indianapolis, Indiana, 47405, United States
Johns Hopkins University

Baltimore, Maryland, 21218, United States
Lund University

Malmö, 214 28, Sweden
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Mayo Clinic, Jacksonville

Jacksonville, Florida, 32224, United States
Mayo Clinic, Rochester

Rochester, Minnesota, 55905, United States
Northwestern University

Chicago, Illinois, 60611, United States
Stanford University

Palo Alto, California, 94304, United States
University College London

London, WC1N 3BG, United Kingdom
University of California, Los Angeles

Los Angeles, California, 90095, United States
University of California, San Francisco

San Francisco, California, 94121, United States
University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
Washington University, St. Louis

St Louis, Missouri, 63130, United States
Wien Center

Miami Beach, Florida, 33140, United States

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