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Lithium shield: could a mood drug guard the brain during neck surgery?

NCT ID NCT05126238

Disease control Sponsor: Negovsky Reanimatology Research Institute Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether giving lithium carbonate before carotid artery surgery could reduce brain damage and confusion after the operation. The trial planned to include 107 adults undergoing elective carotid surgery, but it was terminated early. The goal was to see if lithium could prevent problems like delirium and memory issues that sometimes occur when blood flow to the brain is temporarily stopped during surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

107 people

The number who actually took part.

Started

Nov 2021

Finished

May 2025

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * age \> 18 years * elective carotid artery surgery * general anesthesia * written informed consent Exclusion Criteria: * urgent surgery * recent ( \< 1 month) overt stroke * Mini-mental State Examination \< 20 points * The presence of any mental disorder according to the International Classification of Diseases 11th Revision which is confirmed by a psychiatrist. * The presence of any neuromuscular disease according to the International Classification of Diseases 11th Revision * Hypersensitivity or known allergy to lithium carbonate * History of seizure disorder * History of leukemia * Estimated glomerular filtration rate \< 30 ml/min/1.73 m2 * Left ventricular ejection fraction \< 30% * Heart failure equal 3 or 4 class according to the New York Heart Association Functional Classification * Pregnant or breast-feeding women * Inability to undergo a preoperative assessment for any reason * Previously enrolled in this trial

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Conditions

The condition(s) this trial relates to.

carotid artery disorder carotid stenosis cognitive disorder Emergence Delirium Neuroinflammatory Diseases Postoperative Cognitive Complications Psychomotor Agitation stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Carotid artery diseases Carotid artery stenosis

Contacts and locations

Locations

  • Demikhov Municipal Clinical Hospital 68

    Moscow, Russia

More trials for these conditions

Other studies related to the condition(s) this trial covers.