New PET tracer could spot dangerous plaques before they cause strokes

NCT ID NCT01608516

Terminated Knowledge-focused Sponsor: University of Lausanne Hospitals Source: ClinicalTrials.gov ↗

First seen Jul 16, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This study compares a new imaging tracer, 68Ga-NODAGA-RGD, with standard methods (FDG-PET, MRI, ultrasound) to detect inflamed plaques in the carotid arteries. Twenty people scheduled for plaque-removal surgery will receive the tracer and undergo scans. The goal is to see which technique best identifies unstable, inflammation-prone plaques, using tissue analysis after surgery as the gold standard.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: 68Ga-NODAGA-RGD, a radioactive tracer for PET/CT imaging
What this could lead to: If successful, this imaging method could help identify dangerous artery plaques earlier, potentially preventing strokes.
What could go wrong: This is a small, early-phase study focused on imaging accuracy, not treatment. The tracer may not prove superior to existing methods.

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Conditions

The condition(s) this trial relates to.

atherosclerosis carotid artery disorder Inflammation inflammatory disease Plaque, Atherosclerotic

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATHEROMATOUS PLAQUES CAROTID ARTERY DISEASES INFLAMMATION

Contacts and locations

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Locations

Centre Hospitalier Universitaire Vaudois

Lausanne, Canton of Vaud, 1011, Switzerland

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