Brain scans reveal why dementia changes personality

NCT ID NCT01782248

Terminated Knowledge-focused Sponsor: University Hospital, Strasbourg, France Source: ClinicalTrials.gov ↗

First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time

Summary

This study investigates how Alzheimer's disease and frontotemporal dementia alter a person's sense of self and ability to understand others. Researchers will compare patients with healthy older adults using questionnaires and brain imaging. The goal is to link changes in self-awareness and social cognition to specific brain changes, shedding light on the personality shifts common in dementia.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this research could help explain why people with dementia experience personality changes, potentially guiding future therapies.
What could go wrong: This is an observational study with only 40 participants, so findings may not apply to all dementia patients. It aims to understand, not treat, the condition.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease frontotemporal dementia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER DISEASE FRONTO-TEMPORAL LOBAR DEMENTIA

Contacts and locations

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Locations

Hôpitaux Universitaires de Strasbourg

Strasbourg, 67098, France

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