Alzheimer's drug AL002 safety trial ends early

NCT ID NCT05744401

Terminated Disease control Sponsor: Alector Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study was a long-term extension of an earlier trial, testing the safety and tolerability of AL002 in 197 people with early Alzheimer's disease. Participants received the drug by IV infusion. The trial was terminated, meaning it stopped before completion, so the full safety and effectiveness data are not available. The main goal was to monitor side effects, including brain abnormalities like swelling or small bleeds.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: AL002 (a drug given by IV infusion)
What this could lead to: If successful, this could help confirm whether AL002 is safe enough to continue testing as a potential treatment for early Alzheimer's disease.
What could go wrong: The trial was terminated early, so results are limited. AL002 is still experimental, and previous studies have not yet proven it slows or stops Alzheimer's. Brain swelling or bleeding (ARIA) are known risks with similar drugs.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER'S DISEASE

Contacts and locations

Locations

"Alzheimers Research and Treatment Center-Wellington "

Wellington, Florida, 33449, United States
ASL Biella - Ospedale degli Infermi

Ponderano, Piedmont, 13875, Italy
ASST degli Spedali Civili di Brescia - Spedali Civili di Brescia - INCIPIT - PIN

Brescia, Lombardy, 25123, Italy
Advanced Clinical Institute

Neptune City, New Jersey, 07753, United States
Alfred Health

Melbourne, Victoria, 3004, Australia
Ambulantes Gesundheitszebtrum der Charite GmbH

Berlin, State of Berlin, 12200, Germany
Axiom Brain Health LLC

Tampa, Florida, 33609, United States
Azienda Ospedaliero Universitaria Pisana

Pisa, Italy
Azienda Ospedaliero-Universitaria di Modena - Policlinico di Modena

Modena, Modena, 41126, Italy
Azienda Policlinico Umberto

Rome, Lazio, 00185, Italy
Banner Alzheimer's Institute

Phoenix, Arizona, 85006, United States
Baycrest Health Sciences

Toronto, Ontario, M6A 2X8, Canada
Box Hill Hospital

Box Hill, Victoria, 3128, Australia
Brain Research Center Den Bosch - PPDS

's-Hertogenbosch, North Brabant, 5223 LA, Netherlands
Centro De Atencion Especializada Oroitu

Getxo, Vizcaya, 48993, Spain
Centro de Psiquiatria Biologica

Mendoza, Mendoza Province, 05500, Argentina
Centrum Medyczne NeuroProtect

Warsaw, Masovian Voivodeship, 01-684, Poland
Charité - Universitätsmedizin Berlin

Berlin, State of Berlin, 13125, Germany
Charter Research

Lady Lake, Florida, 32159, United States
Conquest Research LLC - Winter Park - ClinEdge - PPDS

Winter Park, Florida, 32819, United States
EUROMEDIS Sp. z o.o.

Szczecin, West Pomeranian Voivodeship, 70-111, Poland
Feinstein Institute For Medical Research

Manhasset, New York, 11030, United States
Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico

Milan, Lombardy, 20122, Italy
Fondazione IRCCS Di Rilievo Nazionale Istituto Nazionale Neurologico Carlo Besta-VIA MANGIAGALLI 3

Milan, Lombardy, 20133, Italy
Fondazione Policlinico Universitario A Gemelli-Rome

Rome, Lazio, 00168, Italy
Fundacion ACE Instituto Catalan de Neurociencias-Gran via de Carles III, 85 bis

Barcelona, Barcelona, 8028, Spain
Fundacion CITA Alzheimer Fundazioa

San Sebastián, Guipúzcoa, 20009, Spain
Georgetown University Medical Center

Washington D.C., District of Columbia, 20007, United States
Hattiesburg Clinic

Hattiesburg, Mississippi, 39401, United States
Hospital Universitari i Politecnic La Fe de Valencia

Valencia, Valencia, 46026, Spain
Hospital Universitario Doctor Peset

Valencia, Valencia, 46017, Spain
Hospital Universitario Ramon y Cajal

Madrid, Madrid, 28034, Spain
Hospital Viamed Montecanal

Zaragoza, Zaragoza, 50012, Spain
Hospital de La Santa Creu i Sant Pau

Barcelona, Barcelona, 08025, Spain
IRCCS - Centro S. Giovanni di Dio Fatebene fratelli

Brescia, Lombardy, 25125, Italy
Instituto Privado Kremer

Córdoba, Córdoba Province, X5004AOA, Argentina
K2 Medical Research - Maitland

Maitland, Florida, 32751, United States
KaRa Institute of Neurological Disease

Macquarie Park, New South Wales, 2113, Australia
Kawartha Regional Memory Clinic

Peterborough, Ontario, K9H 2P4, Canada
Klinikum rechts der Isar der Technischen Universitaet Muenchen

Munich, Bavaria, 81675, Germany
NZOZ Wroclawskie Centrum Alzheimerowskie

Wroclaw, Lower Silesian Voivodeship, 53-110, Poland
NeuroClin Glasgow

Motherwell, ML1 4UF, United Kingdom
Ospedale Isola Tiberina - Gemelli Isola

Rome, Lazio, 00186, Italy
Progressive Medical Research - ClinEdge - PPDS

Port Orange, Florida, 32127, United States
RE: Cognition Health - Plymouth

Plymouth, Devon, PL6 8BT, United Kingdom
Re-Cognition Health - Bristol

Bristol, Bristol, BS32 4SY, United Kingdom
Re:Cognition Health

London, W1G 9RU, United Kingdom
Re:Cognition Health - Guildford - PPDS

Guildford, Surrey, GU2 7YD, United Kingdom
SFM Clinical Research, LLC

Boca Raton, Florida, 33487, United States
SUNY Upstate Medical Center

Syracuse, New York, 13210, United States
Summit Research Network

Portland, Oregon, 97210, United States
The National Hospital for Neurology and Neurosurgery

London, WC1N 3BG, United Kingdom
University of Cincinnati Medical Center

Cincinnati, Ohio, 45219, United States
Universitätsklinikum Ulm-Oberer Eselsberg 45

Ulm, Baden-Wurttemberg, 89081, Germany

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