Schizophrenia drug trial cut short: only 34 of 250 patients enrolled

NCT ID NCT05368558

Terminated Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested cariprazine (VRAYLAR), an approved schizophrenia drug in the U.S., for people with acute schizophrenia in Japan and Taiwan. Participants received either cariprazine or a placebo for 6 weeks, then could continue on cariprazine for 18 more weeks. The trial was terminated early and enrolled only 34 adults instead of the planned 250, so the findings are limited.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

cariprazine (VRAYLAR)

What this could lead to

If successful, this could confirm cariprazine as a safe and effective option for managing acute schizophrenia symptoms in Asian populations.

What could go wrong

The trial was terminated early with only 34 participants enrolled, far below the planned 250. This limits the reliability of results and raises questions about feasibility or safety issues.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

schizophrenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SCHIZOPHRENIA

Contacts and locations

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Locations

Akita University Hospital /ID# 245941

Akita, Akita, 010-8543, Japan
Asakayama General Hospital /ID# 242732

Sakai, Osaka, 590-0018, Japan
Bali Psychiatric Center /ID# 241597

New Taipei City, New Taipei, 249, Taiwan
Changhua Christian Hospital /ID# 241524

Changhua City, Changhua County, 50006, Taiwan
Chung Shan Medical University Hospital /ID# 241543

Taichung, 40201, Taiwan
Duplicate_Hokkaido University Hospital /ID# 243245

Sapporo, Hokkaido, 060-8648, Japan
Duplicate_University Hospital Kyoto Prefectural University of Medicine /ID# 242443

Kyoto, Kyoto, 602-8566, Japan
Fukuoka University Hospital /ID# 244404

Fukuoka, Fukuoka, 814-0180, Japan
Gifu University Hospital /ID# 246238

Gifu, Gifu, 501-1194, Japan
Goryokai Hospital /ID# 242420

Sapporo, Hokkaido, 002-8029, Japan
Hayakawa Clinic /ID# 242432

Kure, Hiroshima, 737-0111, Japan
Hizen Psychiatric Center /ID# 243239

Kanzaki-gun, Saga-ken, 842-0192, Japan
Holy Cross Hospital /ID# 242673

Toki-shi, Gifu, 509-5142, Japan
International University of Health and Welfare Narita Hospital /ID# 243870

Narita-shi, Chiba, 2868520, Japan
Inuo Hospital /ID# 243310

Tosu-shi, Saga-ken, 841-0081, Japan
Jianan Psychiatric Center, Ministry of Health and Welfare /ID# 241540

Tainan, 71742, Taiwan
Juntendo Univ Koshigaya Hospital /ID# 248502

Koshigaya-shi, Saitama, 343-0032, Japan
Kagawa University Hospital /ID# 243772

Kita-gun, Kagawa-ken, 761-0793, Japan
Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 241528

Kaohsiung City, 807, Taiwan
Kaohsiung Municipal Kai-Syuan Psychiatric Hospital /ID# 241533

Kaohsiung City, Kaohsiung, 802, Taiwan
Kuramitsu Hospital /ID# 242511

Fukuoka, Fukuoka, 819-0037, Japan
Linkou Chang Gung Memorial Hospital /ID# 241520

Taoyuan City, 333, Taiwan
Maizuru Medical Center /ID# 243450

Maizuru, Kyoto, 625-8502, Japan
Mental Support Soyokaze Hospital /ID# 242512

Ueda-shi, Nagano, 386-0401, Japan
Mie University Hospital /ID# 244710

Tsu, Mie-ken, 514-8507, Japan
Minamitoyama Nakagawa Hospital /ID# 243616

Toyama, 939-8073, Japan
Nara Medical University Hospital /ID# 242561

Kashihara-shi, Nara, 634-8522, Japan
Narimasu Kosei Hospital /ID# 243107

Banqiao Qu, Tokyo, 175-0091, Japan
National Center of Neurology and Psychiatry /ID# 242677

Kodaira-shi, Tokyo, 187-8551, Japan
National Hospital Organization Kure Medical Center /ID# 243405

Kure-shi, Hiroshima, 737-0023, Japan
National Taiwan University Hospital - Yunlin Branch /ID# 241537

Douliu, 640, Taiwan
New Taipei Municipal TuCheng Hospital (Built and Operated by Chang Gung Medical /ID# 243653

New Taipei City, 236, Taiwan
Nishigahara Hospital /ID# 243312

Kita-ku, Tokyo, 114-0024, Japan
Numazu Chuo Hospital /ID# 245275

Numazu-shi, Shizuoka, 4108575, Japan
Ongata Hospital /ID# 256975

Hachioji-shi, Tokyo, 192-0153, Japan
Rainbow & Sea Hospital /ID# 242699

Karatsu-shi, Saga-ken, 847-0031, Japan
Sapporo Medical University Hospital /ID# 245135

Sapporo, Hokkaido, 060-8543, Japan
Shin-abuyama Hospital /ID# 243138

Takatsuki, 569-1041, Japan
Shiranui Hospital /ID# 243717

Omuta-shi, Fukuoka, 836-0004, Japan
Taichung Veterans General Hospital /ID# 246200

Taichung, 40705, Taiwan
Taipei City Hospital, Songde Branch /ID# 241600

Taipei, 110, Taiwan
Taipei Veterans General Hospital /ID# 241522

Taipei City, Taipei, 11217, Taiwan
Taniyama Hospital /ID# 242385

Kagoshima, Kagoshima-ken, 891-0111, Japan
Taoyuan Psychiatric Center, MOHW /ID# 241691

Taoyuan, 33058, Taiwan
Tochigi Prefectural Okamotodai Hospital /ID# 248855

Utsunomiya, Tochigi, 329-1104, Japan
Tokushima University Hospital /ID# 250056

Tokushima, Tokushima, 770-8503, Japan
Tokyo Metropolitan Matsuzawa Hospital /ID# 245272

Setagaya-ku, Tokyo, 156-0057, Japan
Tri-Service General Hospital Beitou Branch /ID# 241563

Taipei, 112, Taiwan
TsaoTun Psychiatric Center, MOHW /ID# 246012

Nantou City, 54249, Taiwan
Wakayama Medical University Hospital /ID# 251105

Wakayama, Wakayama, 641-8510, Japan
Yokohama City University Hospital /ID# 244944

Yokohama, Kanagawa, 236-0004, Japan
Yuge Hospital /ID# 242849

Kumamoto, Kumamoto, 861-8002, Japan