Experimental drug aims to curb disinhibition in dementia patients
NCT ID NCT02534038
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a drug called AVP-786 to see if it could safely reduce disinhibition—impulsive or inappropriate behavior—in people with neurodegenerative disorders like Alzheimer's or frontotemporal dementia. The trial planned to include many participants but was terminated early after enrolling only one person. Because of this, we have very little information about whether the drug works or is safe.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
AVP-786 (deuterated dextromethorphan/quinidine)
What this could lead to
If it works, this could point toward a treatment for disinhibition symptoms in people with brain diseases like Alzheimer's or frontotemporal dementia.
What could go wrong
This trial was terminated early with only 1 participant, so results are very limited. It is unclear if the drug is safe or effective.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Cleveland Clinic Lou Ruvo Center for Brain Health
Las Vegas, Nevada, 89106, United States