Brain steroid injection tested for Alzheimer's – but trial halted early
NCT ID NCT03748303
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early study tested a weekly injection of allopregnanolone, a natural brain steroid, in 6 people with early Alzheimer's or mild cognitive impairment. The goal was to find a safe dose and check for side effects. The trial was terminated early, so we have limited information on whether it helps.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Allopregnanolone (a natural brain steroid given as a weekly injection)
What this could lead to
If it works, this could point toward a treatment that slows or improves early Alzheimer's symptoms.
What could go wrong
This was a very early, small Phase 1 trial that was terminated, so results are limited. The drug may not work or could cause side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University of Southern California - Alzheimer Disease Research Center - Healthcare Consultation Center II
Los Angeles, California, 90033, United States