Could a gum infection drug slow Alzheimer's? new trial launches

NCT ID NCT06847321

Recruiting now Disease control Sponsor: Lighthouse Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 6 times

Summary

This study tests a drug called LHP588 in 300 people with mild-to-moderate Alzheimer's who also have a gum infection from P. gingivalis bacteria. The drug aims to target that bacteria to slow down memory and thinking decline. Participants take a daily capsule for up to 48 weeks, and neither they nor their doctors know if they get the real drug or a placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: LHP588 (a drug targeting P. gingivalis bacteria)
What this could lead to: If it works, this could point toward a treatment that slows Alzheimer's progression in people with a specific bacterial infection.
What could go wrong: This is an early Phase 2 trial with only 300 participants. It may fail to show benefit, and targeting bacteria may not affect Alzheimer's symptoms.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER DISEASE ALZHEIMER DISEASE DUE TO P. GINGIVALIS

Contacts and locations

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Locations

ATP Clinical Research, Inc.
RECRUITING

Orange, California, 92866, United States
Adams Clinic Harlem
RECRUITING

New York, New York, 10029, United States
Adams Clinical Boston
RECRUITING

Boston, Massachusetts, 02116, United States
Adams Clinical Bronx
RECRUITING

The Bronx, New York, 10461, United States
Adams Clinical Watertown
RECRUITING

Watertown, Massachusetts, 02472, United States
Alzheimer's Disease Research Center
RECRUITING

Albany, New York, 12208, United States

Contact Email: •••••@•••••
Alzheimer's Research and Treatment Center - Stuart
RECRUITING

Stuart, Florida, 34997, United States

Contact Email: •••••@•••••
Alzheimer's Research and Treatment Center - Wellington
RECRUITING

Wellington, Florida, 33414, United States

Contact Email: •••••@•••••
Anchor Neuroscience
RECRUITING

Pensacola, Florida, 32502, United States
Ascension via Christi Research
RECRUITING

Wichita, Kansas, 67214, United States
Banner Alzheimer's Institute
RECRUITING

Phoenix, Arizona, 85006, United States

Contact Email: •••••@•••••
Barrow Neurological Institute
RECRUITING

Phoenix, Arizona, 85013, United States
Brain Matters Research
RECRUITING

Delray Beach, Florida, 33445, United States

Contact Email: •••••@•••••
CenExel Denver, CO
RECRUITING

Englewood, Colorado, 80113, United States
CenExel Research - Toms River
RECRUITING

Toms River, New Jersey, 08755, United States
CenExel Sherman Oaks
RECRUITING

Sherman Oaks, California, 91403, United States
Cenexel Savannah GA
RECRUITING

Savannah, Georgia, 31405, United States
Center for Advanced Research & Education Flourish-Gainesville
RECRUITING

Gainsville, Georgia, 30501, United States
Clinical Endpoints
RECRUITING

Scottsdale, Arizona, 85258, United States
Clinical Research Professionals - Headlands
RECRUITING

Chesterfield, Missouri, 63005, United States

Contact Email: •••••@•••••
Columbus Memory Center
RECRUITING

Columbus, Georgia, 31909, United States

Contact Email: •••••@•••••
Conquest Research - Lake Nona
RECRUITING

Orlando, Florida, 32832, United States
Headlands PharmaSite
RECRUITING

Pikesville, Maryland, 21208, United States
Headlands Research-EMA
RECRUITING

Plymouth, Massachusetts, 02360, United States
IMA Evaluations
RECRUITING

Albuquerque, New Mexico, 87109, United States
JEM Research Institute
RECRUITING

Atlantis, Florida, 33462, United States
K2 Medical Research Nashville LLC
RECRUITING

Nashville, Tennessee, 37204, United States
Kerwin Research Center, LLC - Oak Cliff
RECRUITING

Dallas, Texas, 75216, United States

Contact Email: •••••@•••••
Kerwin Research Center, LLC in Texas
RECRUITING

Dallas, Texas, 75231, United States

Contact Email: •••••@•••••
NDx Clinical Research
RECRUITING

Dayton, Ohio, 45459, United States

Contact Email: •••••@•••••
Neurological Research Center - Hattiesburg Clinic
RECRUITING

Hattiesburg, Mississippi, 39401, United States
Neuropsychiatric Research Center of Southwest Florida
RECRUITING

Fort Myers, Florida, 33912, United States

Contact Email: •••••@•••••
Northwest Clinical Research Center
RECRUITING

Bellevue, Washington, 98007, United States

Contact Email: •••••@•••••
Oakland Clinical Research
RECRUITING

Oakland, California, 94609, United States
Progressive Medical Research
RECRUITING

Port Orange, Florida, 32127, United States
Re-Cognition Health Fairfax
RECRUITING

Fairfax, Virginia, 22031, United States
Riverside Clinical Research
RECRUITING

Riverside, California, 92506, United States
Summitt Research
RECRUITING

Portland, Oregon, 97210, United States
Tandem Clinical Research - Metairie
RECRUITING

Metairie, Louisiana, 70006, United States
University of Virginia Adult Neurology
RECRUITING

Charlottesville, Virginia, 22903, United States

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