Cough medicine repurposed to fight dementia with lewy bodies

NCT ID NCT04588285

Recruiting now Disease control Sponsor: Helse Fonna Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 2 trial tests whether ambroxol, a common cough medicine ingredient, can slow cognitive decline and improve symptoms in people with early dementia with Lewy bodies. 180 participants will receive either ambroxol or a placebo for 18 months. The study measures changes in thinking, daily function, and psychiatric symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ambroxol (a cough medicine ingredient, repurposed as a potential brain treatment)
What this could lead to: If it works, this could point toward a treatment that slows cognitive decline and eases symptoms in early dementia with Lewy bodies.
What could go wrong: This is a Phase 2 trial, so it's still early. The drug may not work better than placebo, and high doses could cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Lewy body dementia Lewy Body Disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEMENTIA WITH LEWY BODIES

Contacts and locations

Locations

Haraldsplass Deaconess Hospital
RECRUITING

Bergen, Norway
Helse Fonna
RECRUITING

Haugesund, Haugesund, 5504, Norway
Oslo University Hospital
RECRUITING

Oslo, Norway
Stavanger University Hospital
RECRUITING

Stavanger, Norway
Trondheim University Hospital
RECRUITING

Trondheim, Norway
University Hospital North-Norway
RECRUITING

Tromsø, Norway
University Hospital, Akershus
RECRUITING

Hågån, Norway
University Hospital, Akershus
RECRUITING

Lørenskog, Norway

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