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Could blocking stress hormones shield the brain from Alzheimer's?

NCT ID NCT04601038

Recruiting now Disease control Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time

Summary

This study tests whether a drug called CORT108297, which blocks a stress hormone, can improve memory and thinking in people with mild cognitive impairment or those at risk for Alzheimer's disease. Participants take the drug or a placebo for two weeks, then complete memory and attention tests after a stressful task. The goal is to see if reducing stress-related brain changes can help protect cognitive function.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
CORT108297 (a stress hormone blocker)
What this could lead to
If it works, this could point toward a way to slow memory loss by blocking the harmful effects of stress on the brain.
What could go wrong
This is a small, early-phase trial with only 52 participants and a short 2-week treatment period. Results may not apply to everyone, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease Cognitive Dysfunction dementia Memory Disorders

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER DISEASE MEMORY IMPAIRMENT MILD COGNITIVE IMPAIRMENT

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Johns Hopkins School of Medicine

    RECRUITING

    Baltimore, Maryland, 21224, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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