Could a vaccine stop Alzheimer's before it starts? new trial begins

NCT ID NCT07158905

Recruiting now ⭐️ VACCINE ⭐️ Sponsor: Institute for Molecular Medicine Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 05, 2026 · Updated 4 times

Summary

This Phase 1 trial tests an experimental vaccine called AV-1980R that targets tau protein, a key player in Alzheimer's disease. The study enrolls 48 cognitively healthy adults aged 65-80 who have biological signs of early Alzheimer's. Researchers will check if the vaccine is safe and whether it produces antibodies against tau, with the goal of preventing memory loss.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: AV-1980R (tau vaccine)
What this could lead to: If successful, this could lead to a vaccine that prevents Alzheimer's symptoms by targeting tau protein before memory loss begins.
What could go wrong: This is an early Phase 1 safety trial with only 48 people. The vaccine may not trigger a strong immune response or could cause side effects. It is years away from being a proven treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease frontotemporal dementia Nerve Degeneration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER DISEASE PRECLINICAL ALZHEIMER'S DISEASE

Contacts and locations

Locations

Alzheimer's Research and Treatment Center (Columbus)
RECRUITING

Columbus, Georgia, 31904, United States
Alzheimer's Research and Treatment Center (Stuart)
RECRUITING

Stuart, Florida, 34996, United States
Alzheimer's Research and Treatment Center (Wellington)
RECRUITING

Wellington, Florida, 33414, United States
Comprehensive Center for Brain Health
RECRUITING

Boca Raton, Florida, 33433, United States
Palm Springs Community Health Center
RECRUITING

Miami Lakes, Florida, 33014, United States
University of South Florida
RECRUITING

Tampa, Florida, 33613, United States

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