Could this pill ease Alzheimer's psychosis? large trial underway
NCT ID NCT06947941
First seen Jun 24, 2026 · Last updated Jul 01, 2026 · Updated 4 times
Summary
This Phase 3 trial tests whether the drug combination KarXT + KarX-EC can safely reduce psychosis symptoms (like hallucinations and delusions) in people with Alzheimer's disease. About 325 participants aged 55-90 will receive either the drug or a placebo. The study is currently recruiting.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
KarXT (xanomeline/trospium chloride) plus KarX-EC (xanomeline enteric-coated)
What this could lead to
If successful, this could provide a new treatment option to ease psychosis symptoms like hallucinations and delusions in people with Alzheimer's disease.
What could go wrong
This is an early Phase 3 trial, so results are not guaranteed. The drug may not work better than placebo, and side effects are possible. It is not a cure for Alzheimer's.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Locations
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Gilbert Neurology Partners/CCT Research
RECRUITINGGilbert, Arizona, 85297, United States
Contact Phone: •••-•••-••••
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Inland Psychiatric Medical Group.
RECRUITINGChino, California, 91710, United States
Contact Phone: •••-•••-••••
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Insight Clinical Trials LLC - Independence
RECRUITINGIndependence, Ohio, 44131, United States
Contact Phone: •••-•••-••••
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Local Institution - 0001
WITHDRAWNNaples, Florida, 34105, United States
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Local Institution - 0004
NOT_YET_RECRUITINGMotherwell, ML1 4UF, United Kingdom
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Local Institution - 0005
NOT_YET_RECRUITINGExeter, Devon, EX12LU, United Kingdom
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Local Institution - 0009
NOT_YET_RECRUITINGChertsey, Surrey, KT160PZ, United Kingdom
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Local Institution - 0015
WITHDRAWNOxford, Oxfordshire, OX3 7JX, United Kingdom
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Local Institution - 0017
NOT_YET_RECRUITINGSheffield, Yorkshire and the Humber, S47QQ, United Kingdom
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Local Institution - 0018
WITHDRAWNCrowborough, TN6 1NY, United Kingdom
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Local Institution - 0020
NOT_YET_RECRUITINGMacquarie Park, New South Wales, 2113, Australia
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Local Institution - 0023
NOT_YET_RECRUITINGLondon, England, W1G 8TA, United Kingdom
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Local Institution - 0024
NOT_YET_RECRUITINGLondon, WC1N3BG, United Kingdom
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Local Institution - 0025
NOT_YET_RECRUITINGMontreal, Quebec, H4H 1R3, Canada
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Local Institution - 0027
NOT_YET_RECRUITINGWhitby, Ontario, L1N 5S9, Canada
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Local Institution - 0029
NOT_YET_RECRUITINGCleveland, Ohio, 44195, United States
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Local Institution - 0034
NOT_YET_RECRUITINGOsaka, 550-0006, Japan
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Local Institution - 0035
NOT_YET_RECRUITINGNankoku-shi, 783-8505, Japan
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Local Institution - 0040
NOT_YET_RECRUITINGSuita, Osaka, 565-0871, Japan
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Local Institution - 0052
NOT_YET_RECRUITINGNedlands, Western Australia, 6009, Australia
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Local Institution - 0054
NOT_YET_RECRUITINGToronto, Ontario, M6J1H4, Canada
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Local Institution - 1401
NOT_YET_RECRUITINGNaples, Florida, 34105, United States
Contact